Fig. 6

ZHX2 inhibits thyroid cancer cell lung metastasis through S100A14 in vivo. Thyroid cancer cells (8305C) with or without ZHX2 knockdown were transduced with shS100A14 or their control viruses. A The knockdown efficiency of shZHX2 or shS100A14 was determined by WB. These cells were injected into nude mice via the tail vein to establish lung metastasis models. B The diagram shows the flow of the experiment. C Mouse lung tissues were collected to perform H&E staining. Representative images of each group are presented. (Image magnifications of 20 × , scale bar: 500 μm). Quantification of the lung weight (D), metastatic lung fraction (E) and number of metastatic lung nodules (F) was performed. Data are the mean ± SD. One-way ANOVA. *p  < 0.05, ns not significant