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Fig. 5 | Cancer Cell International

Fig. 5

From: miR-30a targets STOX2 to increase cell proliferation and metastasis in hydatidiform moles via ERK, AKT, and P38 signaling pathways

Fig. 5

STOX2 mitigates miR-30a stimulation of proliferation and metastasis in HTR-8 cells. A and B CCK-8 assay showing the proliferation of HTR-8 cells co-transfected with miR-30a mimics and STOX2 cDNA, or with the miR-30a inhibitor and STOX2 siRNA. C and D Colony formation assay for the growth of HTR-8 cells. E and F The viability of HTR-8 cells was analyzed using an EdU assay. The last line is the positive control. G and H Cell migration assessed after co-transfection of the STOX2 cDNA or miR-30a inhibitor and STOX2 siRNA into HTR-8 cells. I and J Cell invasion assay after co-transfection of STOX2 cDNA or miR-30a inhibitor and STOX2 siRNA into HTR-8 cells. Bar = 100 μm. *P < 0 .05 or **P < 0 .01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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