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Fig. 2 | Cancer Cell International

Fig. 2

From: The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance

Fig. 2

The binding of miR-199a-5p to p62 mRNA. A The effect of cisplatin on miR-199a-5p expression in H446 and H446/EP. miR-199a-5p expression was determined using the QPCR assay. B The predicted binding site of miR-199a-5p to p62 mRNA. C Luciferase reporter gene sequence with the alignment of the miR-199a-5p gene at the predicted binding site in Dual-Luciferase Reporter Assay. D Effects of miR-199a-5p on luciferase signal in H446. H446 cells were co-transformed with miR-199a-5p expression vectors and wild-type (WT)-p62 or mutated-p62 vectors. The luciferase signal was determined 24 h after the transformation followed by the addition of substrate. (*p < 0.01)

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Cancer Cell International

ISSN: 1475-2867

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