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Fig. 6 | Cancer Cell International

Fig. 6

From: The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance

Fig. 6

The knockdown and overexpression of miR-199a-5p in H69PR. A The effect of cisplatin and β-elemene on miR-199a-5p expression in H69PR with knockdown or overexpression of miR-199a-5p. MiR-199a-5p expression was determined using the QPCR assay. Overexpression (OE); knockdown (KD); overexpression negative control; knockdown negative control (KDNC). B–D LC3II/LC3I, ATG5, and p62 expressions in H69PR with knockdown of miR-199a-5p. E Representative images of B–D. The expression was measured using the western blotting assay. F Image of autophagolysosomes in cells with drug exposure. The fluorescence images of autophagolysosomes were captured after the MDC staining of cells. G–I LC3II/LC3I, ATG5, and p62 expressions in H69PR with overexpression of miR-199a-5p. J Representative images of B–D. K The MDC staining of autophagolysosomes in cells with drug exposure. (*p < 0.01)

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Cancer Cell International

ISSN: 1475-2867

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