Fig. 1
From: The emerging role of deubiquitylating enzymes as therapeutic targets in cancer metabolism
Structure of six representative subclasses of DUBs. The secondary structure is significantly different among these DUB classes, and the key catalytic site domains in each DUB are shown on the right of the structure. For USP7, we show a schematic diagram of the binding site and mechanism of action of one of the inhibitors. The labeled catalytic site information comes from UniProt (https://www.uniprot.org). UniProtKB and Protein Databank (PDB) codes: Ubiquitin specific peptidase 7 (USP7), Q93009, 1NB8; OTU deubiquitinase (ubiquitin aldehyde binding 2, OTUB2), Q96DC9, 1TFF; BRCA1 associated protein 1 (BAP1), Q92560, 1TQN; Josephin domain containing 2 (JOSD2), Q8TAC2, 6PGV; COP9 signalosome subunit 5 (CSN5), Q92905, 4F7O; MINDY lysine 48 deubiquitinase 1 (MINDY1), Q8N5J2, 5JKN (A chain)