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Fig. 5 | Cancer Cell International

Fig. 5

From: Identification of proteomic markers for prediction of the response to 5-Fluorouracil based neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

Fig. 5

Relationship between genes/proteins and drug sensitivity/pathway activities in rectal cancer. a, b 5-FU resistance analysis of the differentially expressed proteins (DEPs) corresponding to genes based on GDSC/CTRP IC50 drug data. Gene expression correlation with the drug sensitivity was determined using Spearman correlation. A positive correlation means the genes with high expression are resistant to the drug (fluorouracil or 5-fluorouracil), and vise verse. c The role of the DEPs in cancer related-pathways (using GSCALite). Reverse-phase protein array data from The Cancer Proteome Atlas are analyzed to calculate the correlation of genes with cancer-related pathways in rectal cancer. Genes corresponding to the DEPs with activation/inhibition effect on apoptosis, cell cycle and EMT pathways are shown. TR, total responders; PR, poor responders; EMT, epithelial mesenchymal transition; READ, rectal adenocarcinoma

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Cancer Cell International

ISSN: 1475-2867

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