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Fig. 6 | Cancer Cell International

Fig. 6

From: Identification of proteomic markers for prediction of the response to 5-Fluorouracil based neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

Fig. 6

Functional enrichment and protein–protein interaction (PPI). Gene set enrichment analysis (GSEA) results of the whole proteomic data. HALLMARK gene set terms “E2F_TARGETS” (a) and “G2/M_CHECKPOINT” (b) significantly (nominal p < 0.01) upregulated (red) and “EPITHELIAL_MESENCHYMAL_TRANSITION” (c) downregulated (blue) in the TR versus PR group. The top five Gene Ontology (GO) analysis terms in the biological process (d), cellular component (e), and molecular function (f) categories of differentially expressed proteins between the TR and PR group. g The differentially expressed proteins were mapped to canonical pathways using the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. h The PPI network was assessed using the STRING database and visualized by Cytoscape. Color transition of the nodes is based on the ranking calculated by CytoHubba. NES, Normalized Enrichment Scores; TR, total responders; PR, poor responders

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Cancer Cell International

ISSN: 1475-2867

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