Identification of proteomic markers for prediction of the response to 5-Fluorouracil based neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

Table 4 AUCs of potential protein markers and their combinations in the internal discovery cohort and external validation cohort

Group	Marker	AUC	SE	TNR	TPR	p value	95% CI of AUC
Group	Marker	AUC	SE	TNR	TPR	p value	Lower bound	Upper bound
Internal discovery cohort	HSPA4	0.798	0.103	1.00	0.64	0.004	0.561	0.942
	NIPSNAP1	0.808	0.099	0.78	0.82	0.0018	0.572	0.947
	SPTB	0.848	0.091	1.00	0.64	0.0001	0.619	0.967
	Combination 1	0.939	0.051	1.00	0.82	< 0.0001	0.736	0.997
	Combination 2	0.980	0.024	1.00	0.91	< 0.0001	0.797	1.000
	Combination 3	0.859	0.096	0.78	0.91	0.0002	0.631	0.972
External validation cohort	HSPA4	0.672	0.082	0.90	0.47	0.036	0.533	0.791
	NIPSNAP1	0.707	0.078	0.59	0.80	0.008	0.570	0.821
	SPTB	0.693	0.084	0.83	0.53	0.021	0.556	0.810
	Combination 1	0.735	0.070	0.51	0.93	0.0008	0.600	0.844
	Combination 2	0.741	0.086	0.78	0.73	0.005	0.607	0.849
	Combination 3	0.732	0.082	0.90	0.53	0.005	0.597	0.841
	Combination 4	0.780	0.076	0.88	0.67	0.0002	0.650	0.880

ROC receiver operating characteristic, AUC area under the curve, TPR true positive rate, TNR, true negative rate. Combination 1: HSPA4 & NIPSNAP1; Combination2: HSPA4 & SPTB; Combination 3: NIPSNAP1 & SPTB; Combination 4: HSPA4 & NIPSNAP1 & SPTB

ISSN: 1475-2867