Identification of proteomic markers for prediction of the response to 5-Fluorouracil based neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients

Table 5 AUCs of potential protein markers and their combinations in the total internal cohort

Group	Marker	AUC	SE	TNR	TPR	p value	95% CI of AUC
Group	Marker	AUC	SE	TNR	TPR	p value	Lower bound	Upper bound
TR versus MR + PR	HSPA4	0.647	0.102	1.00	0.36	0.148	0.473	0.796
	NIPSNAP1	0.762	0.090	0.78	0.75	0.004	0.594	0.886
	SPTB	0.722	0.087	0.78	0.68	0.011	0.551	0.856
	Combination 1	0.762	0.090	0.78	0.75	0.004	0.594	0.886
	Combination 2	0.849	0.064	0.89	0.79	< 0.0001	0.693	0.945
	Combination 3	0.869	0.063	1.00	0.61	< 0.0001	0.717	0.957
	Combination 4	0.897	0.055	1.00	0.58	< 0.0001	0.752	0.972
TR + MR versus PR	HSPA4	0.748	0.089	0.88	0.64	0.006	0.579	0.876
	NIPSNAP1	0.615	0.097	0.54	0.82	0.233	0.441	0.770
	SPTB	0.703	0.095	0.81	0.64	0.032	0.530	0.841
	Combination 1	0.689	0.107	0.77	0.64	0.078	0.516	0.830
	Combination 2	0.836	0.069	0.69	0.91	< 0.0001	0.677	0.937
	Combination 3	0.710	0.095	0.73	0.73	0.027	0.538	0.847
	Combination 4	0.794	0.087	0.97	0.56	0.0007	0.629	0.909

ROC receiver operating characteristic, AUC area under the curve, TPR true positive rate, TNR true negative rate, TR total responders, MR moderate responders, PR poor responders. Combination 1: HSPA4 & NIPSNAP1; Combination2: HSPA4 & SPTB; Combination 3: NIPSNAP1 & SPTB; Combination 4: HSPA4 & NIPSNAP1 & SPTB

ISSN: 1475-2867