Fig. 1
From: MALAT1-related signaling pathways in colorectal cancer
Characterization of MALAT1. MALAT1 contains a highly conserved triple-helix element at the 3′ end named MALAT1-associated small cytoplasmic RNA (mascRNA) that protects the 3′ end from degradation and facilitates the localization of MALAT1. mascRNA is a tRNA-like structure that is separated from MALAT precursor by tRNA endonucleases RNase P. Then, pre-mature MALAT1 with a short poly(A) tail-like moiety is cleaved by tRNA endonucleases RNase Z. MALAT1 plays functional roles in transcriptional regulation, translation activation, epigenetic regulation, RNA processing, physiological processes, and cancer