Table 1 MALAT1-related signaling pathways in colorectal cancer (CRC)

WNT/β-catenin

–

Promote CRC cell invasion and metastasis

[69]

SFPQ

PTBP2

–

Accelerate CRC cell growth and metastasis

[62]

AKAP-9

–

Stimulate CRC cell growth and invasion

[35]

Snail

−

Promote CRC cell EMT and migration

[56]

–

miR‑619‑5p

Increase the clinicopathological features of patients with CRC

[57]

EZH

E-cadherin

miR-218

Enhance CRC cell EMT, metastasis, and chemoresistance

[22]

SOX9

miR-145

Promote CRC cell proliferation and migration

[64]

DCP1A

miR-203

Enhance CRC cell proliferation and invasion

[65]

HMGB1

miR‐129‐5p

Enhance CRC cell proliferation

[67]

ABC, BCRP, MDR1, MRP1

miR-20b-5p

Enhance CRC cell migration and reduce apoptosis and the sensitivity to drug

[70]

YAP1,

VEGFA, SLUG, TWIST

miR-126-5p

Stimulate EMT and angiogenesis in CRC cells

[72]

LRP6/β-catenin,

RUNX2

miR-15s

Enhance CRC cell metastasis

[73]

–

miR-194-5p

Enhance CRC cells migration and invasion

[74]

EZH2

miR-363-3p

Promote CRC cell proliferation

[58]

LC3-II

miR-101

p62/SQSTM1

Stimulate CRC cell proliferation and autophagy

[76]

–

miR-101-3p

Promote CRC cell viability

[78]

Wnt/β catenin,

Bcl-2

Caspase-3,

Bax

Enhance CRC cell proliferation and decrease apoptosis

[68]

ADAM17

miR-324-3p

Reduce the Ox-sensitivity in CRC cells

[82]

–

hsa-miR-194-5p

Decrease the PFS rate

[83]

RAB14

miR-508-5p

Promote CRC cell progression

[85]

IRE1/XBP1 and PERK/ATF4

–

Promote CRC cell migration and metastasis

[91]

FUT4

PI3K/AKT/mTOR

miR-26a/26b

Promote CRC cell invasion and tumorigenesis

[94]

lincRNA-ROR, lncRNA-p21, p53

–

Increase CRC cell tumorigenesis

[95]

DANCR

QK

Suppress apoptosis in CRC

[96]