Fig. 7
From: PGM1 suppresses colorectal cancer cell migration and invasion by regulating the PI3K/AKT pathway
PGM1 action was related to the PI3K/AKT pathway. A Levels of PI3K, p-PI3K, AKT, p-AKT, Bcl-2, BAX, P21, and Cyclin D1 protein expression in the five groups of HT-29 cells (CTRL, OE-NC, OE-PGM1, shCTRL, and shPGM1) as determined by western blotting. B Protein expression as shown by densitometry. Data were normalized to GAPDH and obtained from three experiments. C Levels of PI3K, p-PI3K, AKT, p-AKT, Bcl-2, BAX, P21, and Cyclin D1 protein expression in the five groups of SW620 cells (CTRL, OE-NC, OE-PGM1, shCTRL, and shPGM1) as determined by western blotting. D Protein expression as shown by densitometry. Data were normalized to GAPDH and obtained from three separate experiments. ***P < 0.001, ****P < 0.0001; ####P < 0.0001