Fig. 1
From: Functions and underlying mechanisms of miR-650 in human cancers
Upstream regulation of miR-650. Multiple factors participate in the upstream regulation of the miR-650 biological process. In the nucleus, transcription of miR-650 is modulated by coupling expression with its homologous gene immunoglobulin lambda and promoted by transcription factors PBX1 and NF-kB. In the cytoplasm, AXIN1 and lncRNAs (DICER-AS1, MEG3, MIR155HG, POU3F3, ZFPM2-AS1, MCTP1-AS1), which account for the major alterations, act as molecular sponges for miR-650 and negatively regulate its biological function, inducing cancer gene deregulation