Fig. 2
From: Functions and underlying mechanisms of miR-650 in human cancers
Target regulators of miR-650, related signalling pathways and induced biological effects. Genesis, differentiation and metastasis of tumours are essentially related to diverse intracellular signalling pathways, such as Jagged/Notch1, TGFβ/SMAD, Wnt/β-Catenin, and FAT/LATS2, which deliver multiple signals to the cell nucleus in a cascade mode and then trigger a series of biological effects. miR-650 functions as a tumour promoter or suppressor by posttranscriptionally regulating the pivotal factors (oncogenic or anti-oncogenic) within these cascades to affect various biological processes, including cell cycle arrest, proliferation, apoptosis, migration, invasion and EMT. The integrated signalling pathways and key factors directly targeted by miR-650 (white blue) are shown