Table 1 Expression of miR-650 in various cancer and relative clinical significance

HCC

Upregulated

Tissues from 130 HCC patients

Microscopic vascular invasion, tumour volume, TNM stage

[30]

HCC

Upregulated

/

/

[31]

HCC

Upregulated

248 HCC tissues and 120 paracarcinomatous HCC tissues

Age, differentiation capability, tumour stage

[34]

FLD/HCC

Upregulated

/

Tumour metastasis

[32]

NSCLC

Upregulated

53 NSCLC tissues and adjacent normal lung tissues

/

[64]

NSCLC

Upregulated

49 NSCLC tissues and adjacent normal tissues

Overall survival rate

[13]

NSCLC

Upregulated

/

/

[37]

LAD

Upregulated

96 LAD tissues and adjacent normal tissues, 44 LAD tissues (received docetaxel-based chemotherapy)

Lymph node metastasis, tumour stage, overall survival rate, docetaxel resistance

[16]

CRC

Downregulated

Tissues from 96 CRC patients

Overall survival rate

[39]

CRC

Upregulated

45 rectal cancer tissues, 22 colon cancer tissues, adjacent noncancerous tissues

Oxaliplatin resistance, tumour growth

[40]

CRC(bioinf)

Downregulated

Tissues from 217 CRC patients

/

[41]

CRC

Upregulated

Tissues from 70 CRC patients

Lymph node metastasis

[42]

CRC

Upregulated

/

/

[14]

GC(bioinf)

Upregulated

Tissues from 90 GC patients, tissues from 90 pre-GC patients, tissues from 45 healthy controls

/

[45]

GC

Upregulated

Tissues from 119 GC patients

Overall survival rate

[46]

GC

Upregulated

93 GC tissues and adjacent normal tissues, 44 LAD tissues (received docetaxel-based chemotherapy)

Tumor growth

[47]

GC

Upregulated

Primary GC tissues

Lymphatic and distant metastasis

[15]

Glioma

Upregulated

168 glioma tissues and 21 normal contral tissues

WHO grade, KPS score, overall survival rate

[49]

Glioma

Upregulated

Tissues from 39 glioma patients

Tumour formation and growth

[50]

Glioma

Downregulated

Tissues from 24 glioma patients

/

[51]

Melonoma

Downregulated

Tissues from 309 melonoma patients

TNM stage, overall survial, progression-free survival

[19]

Melonoma

Downregulated

/

/

[56]

CLL

Downregulated

Peripheral blood from 80 CLL patients and healthy controls

/

[24]

CLL

Upregulated

Peripheral blood from 102 CLL patients and 40 healthy controls

Binet stage, lactate dehydrogenase (LDH) level, time for first treatment

[59]

ALL

Downregulated

/

Prognosis

[58]

AML

Downregulated

Bone marrow and peripheral blood from 40 AML patients and 35 healthy controls

/

[57]

BC

Upregulated

Tissues from BC patients

/

[60]

EC

Upregulated

60 EC tissues and adjacent normal tissues

Tumour size, TNM stage, lymph and distant metastasis

[11]

ATC

Upregulated

12 PTC tissues, 5 ATC tissues, 6 normal tissues

/

[61]

Osteosarcoma

Upregulated

/

/

[18]

OC

Upregulated

/

Tumour weight and volume

[62]

PC

Upregulated

216 PC tissues, 324 benign prostate tissues, 77 normal tissues

Tumour volume, tumour metastasis, mortality of severe

[63]