Table 2 The roles of miR-650 in various cancer cell lines

HCC

HCC cell and LO2

/

LAST2

Tumour promoter

Promotes cell proliferation, migration and invasion; increases cell EMT

[30]

HCC

LO2, SK-HEP-1, HUH-7, LM6 and Li-7

AXIN1

/

Tumour promoter

Promotes cell proliferation, migration and invasion; increases cell EMT

[31]

HCC

THLE-2 (CRL-2706, ATCC)

/

ING4

Tumour promoter

Promotes cell proliferation

[34]

FLD/HCC

SMMC-7721 and BEL-7404

Benzo[a]pyrene

SOCS3/JAK/STAT3

Tumour promoter

Promotes cell motility

[32]

NSCLC

H23, H522, A549, H1299, SPC-A1, 16HBE, HEK293T

/

LATS2

Tumour promoter

Promotes cell proliferation, migration and invasion

[64]

NSCLC

A549, NCI-H460, MRC-5

/

ING4

Tumour promoter

Promotes cell proliferation and invasion

[13]

NSCLC

cell line H1299, 293T

LncRNA MEG3

SLC34A2

Tumour promoter

Promotes cell migration and invasion; strengthens stem cell-like characteristics

[37]

LAD

SPC-A1, NCI-H1299

/

ING4/Bcl-2/Bax

Tumour promoter

Promotes cell growth; enhances the resistance of LAD cells to docetaxel; reduces the sensitivity of LAD cells to docetaxel

[16]

CRC

DLD-1, HCT-8, HEK293T

/

AKT2/GSK3β/E-cadherin pathway

Tumour suppressor

Suppresses cell proliferation, migration and invasion

[39]

CRC

Caco2 and HT29

LncRNA MIR155HG

ANXA2

Tumour promoter

Promotes M2 macrophage polarization and cell proliferation, migration, invasion and oxaliplatin resistance

[40]

CRC(bioinf)

/

NF-κB

NF-κB signalling pathway

Tumour suppressor

/

[41]

CRC

SW480, HT29, SW620, LOVO

/

NDRG2

Tumour promoter

Promotes cell growth; suppresses cell differentiation and apoptosis

[42]

CRC

SW480, SW620, RKO, 320DM, 320HSR, NCI-H716, H508, CCD841CoN

/

RhoA/Rac1 GTPase + ING4/ERK/p38 MAPK

Tumour promoter

Promotes cell proliferation and migration; increases cell EMT

[14]

GC(bioinf)

/

/

/

Tumour promoter

/

[45]

GC

HGC-27, MKN-45 cells, HEK293T

PBX1

LATS2

Tumour promoter

Promotes cell proliferation, invasion and migration; suppresses cell apoptosis

[46]

GC

AGS, HGC-27, MGC-803, SGC-7901, GES-1

LncRNA DICER-AS1

CSR1

Tumour promoter

Promotes cell proliferation, migration; suppresses cell apoptosis

[47]

GC

SNU-16, NCI-N87

/

ING4

Tumour promoter

Promotes cell proliferation and tumorigenesis

[15]

Glioma

/

/

/

Tumour promoter

/

[49]

Glioma

U251, LN229, U373, A172, U87, NHA

NF-κB

RERG-PHLPP2/AKT + ERK + NF-κB

Tumour promoter

Promotes cell proliferation, autophagy, migration and invasion; increases EMT

[50]

Glioma

LN229, U87, U251, LN308, SNB19, H4

/

FAM83F

Tumour suppessor

Promotes cell proliferation

[51]

Melonoma

A375, MV3

LncRNA POU3F3

/

Tumour suppessor

Reduces MGMT-induced DTIC resistance; suppress cell proliferation

[19]

Melonoma

M21, SK-MEL-1, A2058, A375, HEMa-LP

LncRNA ZFPM2-AS1

Notch1

Tumour suppessor

Promotes cell proliferation and migration; suppresses cell apoptosis

[56]

CLL

NALM-6

host gene for IgLλ

CDK1 ING4 EBF3

Tumour suppessor

Suppresses proliferative capacity of B cells

[24]

CLL

CLL cells

/

NDRG2

Tumour promoter

Suppresses cell apoptosis

[59]

ALL

REH, NALM-6, UT-7

/

GATA2/EPOR

Tumour suppressor

/

[58]

AML

K562 cells

/

Gfi1

Tumour suppressor

Suppresses cell proliferation

[57]

BC

UIVC-IDC-6, -9, -10

22q11.2 gene

ING4 NDRG2

Tumour promoter

Increases cell EMT

[60]

EC

HEC-1B, HEC-1 A, Ishikawa, RL-952, hEEC

LncRNA MCTP1-AS1

SMAD7/TGF-β/SMAD pathway

Tumour promoter

Promotes cell proliferation, migration and invasion; increases EMT

[11]

ATC

TPC-1, CAL62, SW1736, 8505 C

/

PPP2CA

Tumour promoter

Promotes cell migration and invasion

[61]

Osteosarcoma

MG-63

/

NFκB + ING4/IL-6

Tumour promoter

/

[18]

OC

hTERT-OME, SCC-15, SCC-4, SCC-9, SCC-25, CAL-27, FaDu, 019

/

Gfi1

Tumour promoter

Promotes cell proliferation, migration and invasion

[62]

PC

PC3, DU145

/

CSR1

Tumour promoter

Promotes cell growth and DNA replication

[63]