Fig. 2
From: BMI1 promotes osteosarcoma proliferation and metastasis by repressing the transcription of SIK1
BMI1 affects OS cells tumorigenesis in vivo. A OS cells treated with 10µM PTC-209 for 48 h and control group were injected subcutaneously into the armpits of nude mice. The tumor volume of the PTC-209 group was significantly larger than that of the control group. Sample size = 7. B Tumor sizes were represented as means of tumor sizes ± SD. C Tumor weights were represented as means of tumor weights ± SD. D Immunofluorescence staining of Ki67 in control and PTC-209 treated group. Sample size = 3. Scale bar: 20 μm. E Quantification of D. F Immunofluorescence of BMI1 in control and PTC-209 treated group. Sample size = 3. Scale bar: 20 μm. G Quantification of F. *p < 0.05, ***p < 0.001, compared with control