Fig. 7
From: BMI1 promotes osteosarcoma proliferation and metastasis by repressing the transcription of SIK1
Downregulation of SIK1 can restore the altered phenotypes caused by the loss of BMI1. A After treated with the indicated way for 48 h, the proliferative ability of OS cells was detected using CCK-8 assays. Sample size = 6. B After treated with the indicated way for 48 h, colony formation assays were conducted in OS cells. Sample size = 3. C Quantification of B. D After treated with the indicated way for 48 h, transwell assays were performed to determine the migration ability of OS cells. Sample size = 3. E Quantification of D. **p < 0.01, ***p < 0.001, compared with PTC-209 + si-NC