Microbial and molecular differences according to the location of head and neck cancers

Table 2 Results of PICRUSt KEGG pathway enrichment analysis

	Level 1	Level 2	Level 3	Rab.win. non-oral	Rab.win.oral	diff.btw
Oral rich bacteria	Unclassified	Cellular Processes and Signaling	Germination	− 0.421	8.339	9.005
	Human diseases	Neurodegenerative diseases	Huntington's disease	0.541	8.378	7.972
	Metabolism	Metabolism of Terpenoids and Polyketides	Biosynthesis of siderophore group nonribosomal peptides	1.232	8.327	7.111
	Metabolism	Xenobiotics Biodegradation and Metabolism	Atrazine degradation	1.559	8.333	6.271
	Human diseases	Neurodegenerative diseases	Prion diseases	2.353	8.343	6.171
Non-oral rich bacteria	Metabolism	Glycan biosynthesis and metabolism	Other glycan degradation	10.295	− 0.612	− 10.855
	Cellular processes	Transport and catabolism	Lysosome	10.270	− 0.458	− 10.537
	Metabolism	Glycan biosynthesis and metabolism	Glycosphingolipid biosynthesis—globo series	10.230	0.474	− 9.590
	Unclassified	Cellular processes and signaling	Electron transfer carriers	10.290	1.406	− 8.713
	Metabolism	Glycan biosynthesis and metabolism	Glycosaminoglycan degradation	10.275	1.553	− 8.588

BH < 0.05 compared to the oral and non-oral (ALDEx2); BH Benjamini-Hochberg
diff.btw cut off > abs(6)
rab.win.non-oral: a vector containing the median clr value for each feature in non-oral, clr centred log-ratio
rab.win.oral: a vector containing the median clr value for each feature in oral
diff.btw: a vector containing the per-feature median difference between condition non-oral and oral
PICRUSt phylogenetic investigation of communities by reconstruction of unobserved states; KEGG Kyoto Encyclopedia of Genes and Genomes

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