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Table 2 Results of PICRUSt KEGG pathway enrichment analysis

From: Microbial and molecular differences according to the location of head and neck cancers

  Level 1 Level 2 Level 3 Rab.win. non-oral Rab.win.oral diff.btw
Oral rich bacteria Unclassified Cellular Processes and Signaling Germination − 0.421 8.339 9.005
Human diseases Neurodegenerative diseases Huntington's disease 0.541 8.378 7.972
Metabolism Metabolism of Terpenoids and Polyketides Biosynthesis of siderophore group nonribosomal peptides 1.232 8.327 7.111
Metabolism Xenobiotics Biodegradation and Metabolism Atrazine degradation 1.559 8.333 6.271
Human diseases Neurodegenerative diseases Prion diseases 2.353 8.343 6.171
Non-oral rich bacteria Metabolism Glycan biosynthesis and metabolism Other glycan degradation 10.295 − 0.612 − 10.855
Cellular processes Transport and catabolism Lysosome 10.270 − 0.458 − 10.537
Metabolism Glycan biosynthesis and metabolism Glycosphingolipid biosynthesis—globo series 10.230 0.474 − 9.590
Unclassified Cellular processes and signaling Electron transfer carriers 10.290 1.406 − 8.713
Metabolism Glycan biosynthesis and metabolism Glycosaminoglycan degradation 10.275 1.553 − 8.588
  1. BH < 0.05 compared to the oral and non-oral (ALDEx2); BH Benjamini-Hochberg
  2. diff.btw cut off > abs(6)
  3. rab.win.non-oral: a vector containing the median clr value for each feature in non-oral, clr centred log-ratio
  4. rab.win.oral: a vector containing the median clr value for each feature in oral
  5. diff.btw: a vector containing the per-feature median difference between condition non-oral and oral
  6. PICRUSt phylogenetic investigation of communities by reconstruction of unobserved states; KEGG Kyoto Encyclopedia of Genes and Genomes