Fig. 5

Correlation between SNAP25 expression and clinical manifestations, and tumor-infiltrating immune cells of PCa. a Expression of SNAP25 between cancer and normal samples. The relationship between SNAP25 expression and T-stage (b), N-stage (c) and pathological Gleason score (d). e SNAP25 expression was significantly negatively correlated with tumor purity and positively correlated with the abundance of several immune cell types in PCa. This included CD8⁺ T cells, CD4⁺ T cells, macrophages, B cells, neutrophils, and dendritic cells. f A heatmap of the correlation between SNAP25 and T cells, B lineage, monocytic lineage, myeloid dendritic cells, cytotoxic lymphocytes, and natural killer cells. Higher SNAP25 expression was associated with more immune infiltration in PCa