Table 1 circRNA as potential oncogenic agent in HCC

Cdr1as

Tissues

Cell lines

Upregulation

Proliferation (+)

Migration (+)

Cdr1as/miR-1287/Raf1

[76]

circHIPK3

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Migration (+)

Growth (+)

circHIPK3/miR-124/AQP3

[70]

circPVT1

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Migration (+)

Growth (+)

Apoptosis (−)

circPVT1/miR-203/HOXD3

circPVT1/miR-3666/SIRT7

[68, 94]

circ_0015756

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

Growth (+)

circ_0015756/miR-7/FAK/Akt

[157]

circ_0091579

Tissues

Cell lines

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

circ_0091579/microRNA-490-3p

[75]

circZNF609

Tissues

Cell lines

Upregulation

Proliferation (+)

Migration (+)

Stemness (+)

circZNF609/miR-15a-5p, 15b-5p/GLI2/Hedgehog

[81]

hsa_circ_0003288

Tissues

Cell lines

Upregulation

Migration (+)

Invasion (+)

hsa_circ_0003288/miR-145/PD-L1 PI3K/Akt

[77]

has_circ_0039053

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Invasion (+)

Growth (+)

has_circ_0039053/miR-637/USP21

[73]

circRASGRF2

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Migration (+)

Growth (+)

circRASGRF2/miR-1224/FAK

[74]

hsa_circ_0056836

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

Growth (+)

hsa_circ_0056836/miR-766-3p/FOSL2

[69]

circGprc5a

Tissues

Cell lines

Animal

Upregulation

Proliferation ( +)

Apoptosis (−)

Growth (+)

circGprc5a/miR-1283/YAP1/TEAD1

[96]

circBACH1

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Growth (+)

CircBACH1/HuR/p27

[82]

circ-ZEB1.33

Tissues serum

Cell lines

Upregulation

Proliferation (+)

circ-ZEB1.33/miR-200a-3p/CDK6

[83]

circ‐HOMER1

Tissues

Cell lines

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

Apoptosis (−)

circ‐HOMER1/miR‐1322/CXCL6

[97]

Cul2 circRNA

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

Growth (+)

Twist1/Cul2 circRNA/Vimentin

[87]

circCRIM1

Tissues

Cell lines

Upregulation

Proliferation (+)

Angiogenesis (+)

circCRIM1/miR-378a-3p/SKP2

[89]

circ_0001955

Tissues

Cell lines

Upregulation

Proliferation (+)

Migration (+)

Angiogenesis (+)

Apoptosis (−)

circ_0001955/miR-646/FZD4

[90]

circGFRA1

Tissues

Cell lines

Upregulation

Proliferation (+)

Migration (+)

Angiogenesis (+)

circGFRA1/miR-149

[91]

circ_0067934

Tissues

Cell lines

Upregulation

Growth (+)

Metastasis (+)

circ_0067934/miR-1324/FZD5/Wntβ-catenin axis

[78]

circZFR

Tissues

Cell lines

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

Apoptosis (−)

circZFR/miR-3619–5p/CTNNB1/Wntβ-catenin

circZFR/miR-511/AKT1/β-catenin

CircZFR/MAP2K1

[79, 80]

hsa_circ_0085616

Tissues

Cell lines

Upregulation

Proliferation (+)

Migration (+)

Invasion (+)

Apoptosis (−)

β-catenin, p-ERK, and p-AKT

[84]

hsa_circ_102559

Tissues

Cell lines

Animal

Upregulation

Migration (+)

Growth (+)

hsa_circ_102559/miR-130a-5p/ANXA2

[95]

circFAT1

Tissues

Cell lines

Animal

Upregulation

Invasion (+)

Proliferation (+)

Growth (+)

circFAT1/miR-30a-5p/REEP3

[98]

circCSPP1

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Invasion (+)

Migration (+)

Apoptosis (−)

Growth (+)

circCSPP1/miR-1182/RAB15

circCSPP1/miR-577/CCNE2

[99, 100]

circMAP2K4

Tissues

Cell lines

Upregulation

Proliferation (+)

circMAP2K4/hsa-miR-139-5p/YTHDF1

[93]