Table 2 circRNA as suppressor in HCC
From: The function and regulation network mechanism of circRNA in liver diseases
circRNA | Source of sample | Expression | Function | Mechanism/pathway | Refs. |
|---|---|---|---|---|---|
circARSP91 | Tissues Cell lines Animal | Downregulation | Growth (−) | AR/ADAR1/Cir ARSP91 | [112] |
circRNA7 | Cell lines | Downregulation | Migration (−) Invasion (−) Vasculogenic mimicry (−) | AR/circRNA7/miRNA7-5p/VE-Cadherin/Notch4 | [111] |
circMTO1 | Tissues Cell lines Animal | Downregulation | Proliferation (−) Invasion (−) Growth (−) Apoptosis (+) | circMTO1/miR9/p21 | [101] |
circRNA-5692 | Tissues Cell lines Animal | Downregulation | Proliferation (−) Invasion (−) EMT (−) Growth (−) Apoptosis (+) | circRNA-5692/miR-328-5p/DAB2IP | [104] |
circSMAD2 | Tissues Cell lines | Downregulation | Migration (−) Invasion (−) EMT (−) | circSMAD2/miR-629 | [103] |
circADAMTS13 | Tissues Cell lines | Downregulation | Proliferation (−) Apoptosis (+) | circADAMTS13/miR-484 | [102] |
hsa_circ_0079929 | Tissues Cell lines Animal | Downregulation | Proliferation (−) Growth (−) | PI3K/AKT/mTOR | [108] |
circ_0004913 | Tissues Cell lines Animal | Downregulation | Proliferation (−) Migration (−) Invasion (−) Growth (−) | circ_000491/miR-184/HAMP/JAK2/STAT3/AKT | [109] |
hsa_circ_0004018 | Tissues Cell lines Animal | Downregulation | Proliferation (−) Migration (−) Growth (−) Apoptosis (+) | hsa_circ_0004018/miR-626/DKK3 | [110] |
hsa_circ_0005986 | Tissues Cell lines | Downregulation | Proliferation (−) | hsa_circ_0005986/miR-129-5p/Notch1 | [105] |
circC3P1 | Tissues Cell lines Animal | Downregulation | Proliferation (−) Migration (−) Invasion (−) Growth (−) | circC3P1/miR4641/PCK1 | [106] |
circSETD3 | Tissues Cell lines Animal | Downregulation | Growth (−) Proliferation (−) | circSETD3/miR421/MAPK14 | [107] |