Table 3 circRNA as biomarker in HCC

circZKSCAN1

Tissues

Cell lines

Animal

Downregulation

Growth (−)

Migration (−)

Invasion (−)

Function as a ceRNA

AUC (0.834)

Sensitivity (82.2%)

Specificity (72.4%)

[115]

circ-EPHB4

Tissues

Cell lines

Animal

Downregulation

Proliferation (−)

Migration (−)

Invasion (−)

Apoptosis (+)

Growth (−)

circ-EPHB4/HIF-1α/HIF-1α-PI3K-AKT and HIF-1α-ZEB1

AUC (0.861)

Sensitivity (88.9%)

Specificity (97.2%)

[118]

circ-TCF4.85

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Migration (+)

Invasion (+)

Growth (+)

Apoptosis (−)

circ-TCF4.85/miR-486-5p/ABCF2

AUC (0.891) Sensitivity (86.8%)

Specificity (87.0%)

[117]

hsa_circ_0003998

Tissues

Cell lines

Blood samples

Upregulation

–

Sponging miR-143-3p and PCBP1

AUC (0.894)

Sensitivity (84.0%)

Specificity (80.0%)

[53]

hsa_circ_0001445

Tissues

Cell lines

Downregulation

Proliferation (−)

Migration (−)

Invasion (−)

Apoptosis (+)

–

AUC (0.862)

Sensitivity (94.2%)

Specificity (71.2%)

[126]

circRNA 0068669

Tissues

Cell lines

Downregulation

Associated with MVI and TNM stages

–

AUC (0.640)

Sensitivity (59.0%)

Specificity (71.0%)

[120]

has_circ_0005075

Tissues

Cell lines

Upregulation

Proliferation (+)

Migration (+)

Invasion (+)

335miR-23b-5p, miR-93-3p, miR-581, miR-23a-5p

AUC (0.940)

Sensitivity (83.3%)

Specificity (90.0%)

[116]

hsa_circ_0016788

Tissues

Cell lines

Animal

Upregulation

Proliferation ( +)

Invasion ( +)

Apoptosis ( +) Growth (−)

hsa_circ_0016788/miR-486/CDK4

AUC (0.913) (95% CI 0.885–0.941)

[119]

circ-FOXP1

Tissues

Cell lines

Animal

Upregulation

Proliferation (+)

Invasion (+)

Apoptosis (−)

circ-FOXP1/miR-875-3p, miR-421/SOX9

AUC (0.9318)

(95% CI 0.893–0.971)

[125]

circRNA_104075

Tissues

Cell lines

Animal

Upregulation

–

circRNA_104075/miR-582-3p/YAP

AUC (0.973)

Sensitivity (96.0%)

Specificity (98.3%)

[124]

circ-CDYL

Tissues

Cell lines

Animal

Upregulation

–

circ-CDYL/miR-892, miR-328-3p/HDGF and HIF1AN

AUC (0.640)

(95% CI 0.550–0.720)

127

hsa_circ_0076251

Tissues

Downregulation

–

–

AUC (0.738)

Sensitivity (71.3%)

Specificity (64.0%)

[122]

hsa_circ_0028502

Tissues

Downregulation

–

–

AUC (0.675)

Sensitivity (72.1%)

Specificity (58.0%)

[122]