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Fig. 5 | Cancer Cell International

Fig. 5

From: LINC01806 mediated by STAT1 promotes cell proliferation, migration, invasion, and stemness in non-small cell lung cancer through Notch signaling by miR-4428/NOTCH2 axis

Fig. 5

MiR-4428 is a downstream factor of LINC01806. A, B. Subcellular fractionation and FISH assays (scale bar = 10 μm) were carried on for the localization of LINC01806 in NSCLC cells. C The binding affinity of LINC01806 and candidate miRNAs was evaluated via RNA pull down assay. D StarBase projected the alignment between LINC01806 and miR-4428, and the mutated binding sites on LINC01806 were also shown. E The overexpression efficacy of miR-4428 mimics was tested via RT-qPCR. F The luciferase activity of LINC01806-Wt and LINC01806-Mut in H1650 and H1299 cells after transfection with miR-4428 mimics was detected through luciferase reporter assay. **P < 0.01, n.s. no significance

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Cancer Cell International

ISSN: 1475-2867

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