Fig. 3

Cytogenetic changes indicative of cytotoxicity in the stomach epithelium of patients under omeprazole (OME) therapy by the formation of A binucleated cells and B pyknosis. WG (Without Gastritis, n = 32); WG + OME (Without Gastritis + OME, n = 24), G (Gastritis-n = 26); G + OME (Gastritis + OME, n = 26), G + HP (Gastritis + H. pylori, n = 22); G + HP + OME (Gastritis + H. pylori + OME, n = 22). Values represent the mean ± S.D.M. The differences between the groups were determined by Analysis of Variance (ANOVA), followed by the Bonferroni test (post hoc test). Significances were observed for p < 0.0001, a, b, c, d, and e in relatated to SG, SG + OME, G, d G + OME, and G + HP, respectively