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Fig. 1 | Cancer Cell International

Fig. 1

From: Exosomal miR-301a-3p from esophageal squamous cell carcinoma cells promotes angiogenesis by inducing M2 polarization of macrophages via the PTEN/PI3K/AKT signaling pathway

Fig. 1

miR-301a-3p is expressed at high levels in ESCC tissues and cells and shows enrichment in ESCC-derived exosomes. a miRNAs targeting the PTEN gene were predicted using Target Scan, miRDB, and miDIP. b miRNA expression in ESCC tissues was illustrated using a Volcano plot. Each dot represents one miRNA. The dot representing miR-301a-3p is red in color, implying that miR-301a-3p was significantly upregulated in ESCC patients. c–e Quantification of miR-301a-3p expression in 20 pairs of fresh ESCC tissues and corresponding adjacent normal esophageal mucosa tissues (c), four ESCC cell lines KYSE150, EC109, EC9706, and TE1 and one normal esophageal mucosal cell line Het-1A (d), and EC9706 cells and exosomes secreted by EC9706 cells (e) using qRT-PCR. **p < 0.01, ***p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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