Table 1 The distribution of mutations across the primary tissue types that are curated by COSMICÂ database
Tissue/sub-tissue | Histology | Sub histology | Point mutations (%) | Copy number variation (%) | Hypomethylation (%) | |
|---|---|---|---|---|---|---|
Gain | Loss | |||||
Bile duct/gallbladder | Carcinoma | Small cell carcinoma | 5.88 (n = 17) | / | / | / |
Bile duct/bile duct | Carcinoma | Adenocarcinoma | 3.5 (n = 457) | / | / | / |
Breast | Carcinoma | / | 0.14 (n = 1429) | 0.18 (n = 1131) | 0.35 (n = 1131) | / |
Central nervous system/cerebellum | Glioma | Astrocytoma Grade IV | 7.14 (n = 14) | / | / | / |
Cervix | Carcinoma | Squamous cell carcinoma | 2.83 (n = 318) | / | 0.33 (n = 299) | / |
Endometrium | Carcinoma | Endometrioid carcinoma | 3.61 (n = 581) | / | 0.19 (n = 530) | / |
Haematopoietic and lymphoid | Lymphoid neoplasm | Follicular lymphoma | 2.33 (n = 43) | / | / | / |
Kidney | Carcinoma | Papillary renal cell carcinoma | 0.59 (n = 340) | / | 1.05 (n = 286) | / |
Liver | Carcinoma | Hepatocellular carcinoma | 0.69 (n = 1012) | 0.15 (n = 660) | 0.15 (n = 660) | / |
Lung | Carcinoma | Adenocarcinoma | 3.48 (n = 1035) | 0.53 (n = 375) | 0.27 (n = 375) | / |
Lung | Carcinoma | Squamous cell carcinoma | 2.62 (n = 762) | 0.4 (n = 500) | / | / |
Ovary | Carcinoma | Serous carcinoma | 0.59 (n = 673) | 0.18 (n = 568) | 0.18 (n = 568) | / |
Oesophagus | Carcinoma | Adenocarcinoma | 0.64 (n = 467) |  |  |  |
Pancreas | Carcinoma | Ductal carcinoma | 0.7 (n = 1281) |  |  |  |
Prostate | Carcinoma | Adenocarcinoma | 0.48 (n = 1462) | / | / | / |
Skin | Malignant melanoma | / | 8.35 (n = 826) |  |  |  |
Stomach | Carcinoma | Adenocarcinoma | 2.35 (n = 596) | / | / | / |
Thyroid | / | neoplasm | 6.67 (n = 15) | / | / | / |
Upper aerodigestive tract/ head neck | Carcinoma | Squamous cell carcinoma | 0.8 (n = 519) | 0.58 (n = 626) | / | 0.6 (n = 496) |
Urinary tract/Bladder | Carcinoma | / | 1.44 (n = 555) | 0.5 (n = 399) | / | 10.62 (n = 273) |