Fig. 2

EIF3B knockdown reduces HNSCC in vitro and in vivo. A EIF3B was knocked down using shRNAs, and the knockdown efficiency was examined via qRT–PCR in Fadu and Cal27 cells. B, C CCK8 assay indicating that EIF3B knockdown attenuated the proliferation of Fadu and Cal27 cells. D Cell apoptosis rate increased in Fadu and Cal27 cells in the EIF3B knockdown groups. E Cell invasion examined with a transwell assay in Fadu and Cal27 cells. F Cell migration examined with wound healing assays in Fadu and Cal27 cells. G In vivo nude mouse xenograft results showed that EIF3B knockdown reduced the tumor volume of Fadu cells (n = 5). All assays were replicated three times. *, P < 0.05; **, P < 0.01