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Fig. 5 | Cancer Cell International

Fig. 5

From: Eukaryotic translation initiation factor 3 subunit B promotes head and neck cancer via CEBPB translation

Fig. 5

EIF3B regulates CEBPB target expression and its role in HNSCC. A Expression of the CEBPB targets in the control and EIF3B knockdown groups (shEIF3B) is shown using a heatmap. B qRT–PCR was applied to validate the expression of CEBPB targets, and SPRY4, NFKBIA, IL6R and CCNG2 showed a consistent trend with the RNA-seq results. C Coexpression of EIF3B and CEBPB targets was validated with the TCGA HNSCC dataset, and EIF3B showed a significant positive correlation with CEBPB, SLPI, IL6R, and SPRY4 and a negative correlation with CCNG2. D EIF3B promotes HNSCC progression by directly binding and promoting the translation of CEBPB and activating the transcription and expression of downstream targets (e.g., IL6R and CCNG2)

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Cancer Cell International

ISSN: 1475-2867

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