Fig. 2

LRRN4 expression positively correlated with the clinical outcome of CRC patients at both the mRNA and protein levels. A Kaplan–Meier curves of PFS of CRC from TCGA based on the expression of LRRN4 mRNA, B Kaplan–Meier curves of OS of CRC from TCGA based on the expression of LRRN4 mRNA, C Representative IHC images with low expression and high expression of LRRN4 protein. Magnification 200 × , scale bars correspond to 100 μm (left) and magnification 400 × , scale bars correspond to 50 μm (right). Arrows indicate cells with low or high expression of LRRN4. D Patients percent with high or low LRRN4 expression in CRC and normal colorectal tissues. E Kaplan–Meier curves of OS of CRC in a Chinese cohort based on the expression of LRRN4 protein