Prognostic value and biological function of LRRN4 in colorectal cancer

Table 4 Univariate and multivariate Cox proportional hazards regression analyses for OS of LRRN4 and clinical features

Variables	Univariable Cox			Multivariable Cox
Variables	HR	95%CI	p value	HR	95%CI	p value
LRRN4 (high vs. low)	2.936	1.441–5.982	0.003	2.364	1.104–5.062	0.027
Age	1.004	0.983–1.026	0.713	1.003	0.983–1.024	0.769
Gender (female vs. male)	0.766	0.413–1.418	0.396	0.891	0.462–1.720	0.731
Location (rectum vs. colon)	1.049	0.545–2.019	0.885	1.400	0.692–2.829	0.349
Histological type (nonmucinous vs. mucinous)	1.077	0.566–2.046	0.822	0.914	0.425–1.965	0.818
Pathologic stage (III/IV vs. I/II)	3.189	1.564–6.501	0.001	2.282	1.051–4.952	0.037
Adjuvant chemoradiotherapy (yes vs. no)	0.721	0.387–1.345	0.304	0.748	0.385–1.454	0.392
Grade (1/2 vs. 3)	0.424	0.102–1.758	0.237	0.406	0.090–1.823	0.239

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