Fig. 1

High expression of HDAC3 is indicative of poor prognosis in patients with ESCC. A HDAC3 expression in ESCC and adjacent tissues (n = 79). B HDAC3 expression in HEECs and ESCC cell lines (EC9706, Eca109, EC1 and KYSE-150). C Immunohistochemistry analysis of HDAC3 protein in representative ESCC and adjacent tissues (scale bar: 25 μm). D HDAC3 protein expression in ESCC and adjacent tissues (n = 79). E HDAC3 protein expression in HEECs and EC cell lines (EC9706, Eca109, EC1 and KYSE-150). F Correlation between HDAC3 expression and OS of patients with ESCC (n = 79). * p < 0.05 vs. adjacent tissues, HEECs or patients with low expression of HDAC3. Measurement data were expressed as mean ± standard deviation derived from at least 3 independent experiments. Data between ESCC and adjacent tissues were compared by paired t test. Data comparison among multiple groups was conducted by one-way ANOVA, followed by Tukey’s post hoc test. Survival rate of patients was calculated by Kaplan–Meier method and survival difference was tested by log-rank