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Fig. 5 | Cancer Cell International

Fig. 5

From: Silencing of histone deacetylase 3 suppresses the development of esophageal squamous cell carcinoma through regulation of miR-494-mediated TGIF1

Fig. 5

TGIF1 inactivates the TGFβ signaling pathway to enhance ESCC cell malignant phenotypes. A Expression of the TGFβ signaling pathway-related proteins (Smad2, Smad4 and TGF-βRII) in ESCC and adjacent tissues normalized to GAPDH. n = 79. * p < 0.05 vs. adjacent tissues. B Expression of the TGFβ signaling pathway-related proteins (Smad2, Smad4 and TGF-βRII) in EC9706 and Eca109 cells treated with oe-TGIF1 or in combination with SRI-011381 normalized to GAPDH. C Proliferation of EC9706 and Eca109 cells treated with oe-TGIF1 or in combination with SRI-011381. D Apoptosis of EC9706 and Eca109 cells treated with oe-TGIF1 or in combination with SRI-011381. E Migration of EC9706 and Eca109 cells treated with oe-TGIF1 or in combination with SRI-011381. F Invasion of EC9706 and Eca109 cells treated with oe-TGIF1 or in combination with SRI-011381. G Protein levels of cleaved caspase-3, total caspase-3, MMP-2 and MMP-9 normalized to GAPDH in EC9706 and Eca109 cells treated with oe-TGIF1 or in combination with SRI-011381. In Panel B-G, *p < 0.05 vs. EC9706 and Eca109 cells treated with oe-TGIF1 + DMSO. #p < 0.05 vs. EC9706 and Eca109 cells treated with oe-TGIF1 + SRI-011381. Measurement data were expressed as mean ± standard deviation derived from at least 3 independent experiments. Data between ESCC and adjacent tissues were compared by paired t test while data comparison between other two groups was analyzed by unpaired t test

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Cancer Cell International

ISSN: 1475-2867

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