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Fig. 2 | Cancer Cell International

Fig. 2

From: Biological causes of immunogenic cancer cell death (ICD) and anti-tumor therapy; Combination of Oncolytic virus-based immunotherapy and CAR T-cell therapy for ICD induction

Fig. 2

OVs could enhance the recruitment, activation, and expansion of CAR T cells by generating type I INFs and switching the tumor milieu from immunologically "cold" to a "hot" state. On the one hand, OVs cause tumors to die through immunogenic cell death (ICD), remove physical barriers, and send out a warning signal to T cells. OVs, on the other hand, can express the CD19 upon tumor cells as a specific target for CAR-T, enhancing CAR-T-mediated lysis. OVs oncolytic viruses, CAR-T cell Chimeric antigen receptor T cell, ICD Immunogenic cell death, TAAs tumor-associated antigens

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Cancer Cell International

ISSN: 1475-2867

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