Fig. 1
From: DNA repair and damage pathways in mesothelioma development and therapy
A schematic diagram depicting the effect of Hedgehog signaling on the cancer development. Following the binding of HH ligands to the PTCH receptor, the inhibitory effect of PTCH on SMO protein is removed, leading to GLI-SuFu separation and GLI translocation to the nucleus and finally protein expression. HH Hedgehog, SMO Smoothened, SuFu suppressor of fused protein