Fig. 3
From: DNA repair and damage pathways in mesothelioma development and therapy
Alteration in expression and activation of calcium signaling in mesothelioma cells. T-type Ca2 + channels overexpression increases Ca2 signaling and tumor development. CRT and BAP1 overexpression keep Ca2+ in the ER, reducing Ca2 + uptake into the mitochondria and inhibiting cell apoptosis. BAP1 BRCA1 associated protein 1, CRT Calretinin, E; endoplasmic reticulum