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Fig. 1 | Cancer Cell International

Fig. 1

From: Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells

Fig. 1

Signaling pathways and proteins involved in chondrogenic differentiation of mesenchymal stem cells. R-SMAD-dependent TGF-β and Hedgehog pathways can promote the overexpression of Sox9, whereas Notch and Wnt pathways can inhibit chondrogenic transcription factor Sox9. FGF can act on R-SMAD-independent TGF-β pathway, thus playing a part in chondrogenic differentiation. There are other molecules that interact with Sox9, such as osteogenic transcription factor Runx2, peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1-α) and the member of histone acetyltransferase family P300/CBP

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Cancer Cell International

ISSN: 1475-2867

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