Table 1 Up-regulated circRNAs and Ovarian cancer

CircMUC16

3 EOC tissues and 4 healthy ovarian tissues/6-week-old BALB/c nude mice

SKOV3, ES-2, A2780 and CAOV-3

miR-199a-5p, Beclin1, RUNX1 and ATG13

↑↑ circMUC16: ↑ autophagy flux of SKOV3 cells

↑ autophagy flux of SKOV3 cells: ↑ EOC invasion and metastasis

[9]

circRNA_MYLK

46 pairs of tumor tissues and ANCTs

SKOV3, OVCAR3, PEO1, 3AO, A2780, CAOV3 and HOSEPiCs

miR-652

Patients with high levels of circRNA_MYLK showed a higher pathological staging and a lower OS rate

∆ circRNA_MYLK: ↓ cell proliferation

[10]

circRNA-UBAP2

20 pairs of tumor tissues and ANCTs

SKOV3, No. KL; OVCAR-3, No. H-OVCAR-3; ES-2, No. H-ES-2 and A2780, No. H-A2780 and IOSE80

miR-382-5p/PRPF8 axis

↑↑ circRNA-UBAP2: ↑ proliferation and ↓ apoptosis via sponging miR-382

[11]

circRNA-UBAP2

24 pairs of tumor tissues and ANCTs

A2780, HEY, OVCAR3, HO8910, SKOV3 and IOSE

miR-144

Expression of circRNA-UBAP2 was negatively associated with TMN stage and five-year survival of OC patients

↑↑ circRNA-UBAP2: ↑ proliferation and migration via sponging miR-144

[12]

circWHSC1

79 patients and 13 healthy controls/4-week-old female BALB/c nude mice

CAOV3 and OVCAR3

miR-145, miR-1182, MUC1 and hTERT

↑↑ circWHSC1: ↑ cell proliferation, migration and invasion, and ↓ cell apoptosis via sponging miR-145 and miR-1182

[14]

Hsa_circ_0013958

45 pairs of tumor tissues and ANCTs

A2780, OVCAR‐3 and HOSEpiC

–

High levels of Hsa_circ_0013958 were related to patient FIGO stage and lymph node metastasis

∆ hsa_circ_0013958: ↓ proliferation, migration, and invasion and ↑ apoptosis

[15]

Circ_0013958

30 pairs of tumor tissues and ANCTs/5-week-old female BALB/c nude mice

HOSE, SKOV3 and CAOV3

miR-637/PLXNB2 axis

∆ circ_0013958: ↓ proliferation, migration, invasion, and ↑ apoptosis

[16]

circFGFR3

35 pairs of tumor tissues and ANCTs

OSE, SKOV3, A2780, OV2008 and IGROV1

miR-29a-3p/E2F1 axis

↑↑ circFGFR3: ↑ EMT process

[17]

hsa_circRNA_102958

41 pairs of tumor tissues and ANCTs

OC cell lines and IOSE80 cells

miR-1205/SH2D3A axis

∆ hsa_circRNA_102958: ↓ proliferation, migration and invasion

[18]

circ_0072995

40 pairs of tumor tissues and ANCTs/4 to 6-week-old BALB/c nude mice

HO8910, A2780, and IOSE80

miR-147a/CDK6 axis

↑↑ circ_0072995: ↑ cell proliferation, migration and ↓ apoptosis

[19]

circ_0072995

47 pairs of tumor tissues and ANCTs/6-week-old female BALB/c nude mice

IOSE-80, OVCAR-3 and SK-OV-3

miR-122-5p/SLC1A5 axis

∆ circ_0072995: ↓ cell proliferation, migration, invasion and ↑ cell apoptosis

[20]

circEPSTI1

50 pairs of tumor tissues and ANCTs/4‐week‐old BALB/c nude mice

–

miR-942/EPSTI1 axis

∆ circEPSTI1: ↓ cell proliferation, invasion and ↑ apoptosis

[21]

circ-LOPD2

normal ovarian tissue, benign tumor, borderline tumor and ovarian cancer tissues

CAOV3, A2780 and OVCAR3

miR-378

∆ circ-LOPD2: ↓ cell growth

[22]

circGFRA1

50 pairs of tumor tissues and ANCTs/4-week old BALB/c nude mice

OV119 and A2780

miR-449a/ GFRA1 axis

∆ circGFRA1: ↓ cell proliferation and invasion and ↑ apoptosis

[23]

circ0004390

10 ovarian cancer tissues and 6 normal ovarian tissues

KOV3, HeyA8, OVCAR429 and HEK- 293 T

miR-198/MET axis

∆ circ0004390: ↓ proliferation

[24]

circKIF4A

50 pairs of tumor tissues and ANCTs/4-week-old female BALB/c nude mice

CAOV3 and SKOV3

miR-127/ JAM3 axis

∆ circKIF4A: ↓ cell proliferation and migration

[25]

circ_0000554

–

HO8910

miR-567

↑↑ circ_0000554: ↑ cell growth, invasion, and EMT process

[26]

circKRT7

5-week-old BALB/c mice

SKOV3, ES-2, CoC1, Caov-3, and Caov-4

miR-29a-3p/COL1A1 axis

∆ circKRT7: ↓ cell proliferation, migration and invasion via sponging miR-29a-3p

[27]

circCELSR1

4-week-old female athymic nude mice

SKOV3, A2780, IGROV1, CAOV3, and IOSE80

miR-598/ BRD4 axis

∆ circCELSR1: ↓ proliferation, migration, invasion and EMT process and ↑ apoptosis

[28]

circCELSR1

36 pairs of tumor tissues and ANCTs/6-week-old female BALB/c athymic nude mice

SKOV3, HeyA-8 and IOSE-80

miR-1252/FOXR2 axis

∆ circCELSR1: ↓ cell growth, ↑ G0/G1 arrest and apoptosis

[29]

circCELSR1

–

–

miR-149-5p/SIK2 axis

∆ circCELSR1: ↓ viability, colony formation and cell cycle process, ↑ paclitaxel sensitivity and cell apoptosis

[30]

circHIPK3

69 pairs of tumor tissues and ANCTs

A2780, HO8910, SKOV3, CAOV3 and HOEC

–

Patients with higher levels of circHIPK3 showed lymph node invasion, FIGO stage, and worse DFS and OS

[31]

circHIPK3

66 pairs of tumor tissues and ANCTs

SKOV3

miR-7/VEGF axis

∆ circHIPK3: ↓ tumorigenicity of ovarian cancer cells, proliferation and ↑ apoptosis

[32]

circRAB11FIP1

ovarian cancer tissues and serum samples from 70 EOC and 30 matched non-carcinoma tissue samples/6-week-old BALB/c nude mice

SKOV3

miR-129/ ATG7 and ATG14

∆ circRAB11FIP1: ↓ autophagic flux of ovarian cancer SKOV3 cells

↑↑ circRAB11FIP1: ↑ autophagy, proliferation and invasion

[13]

Hsa_circ_0009910

50 pairs of tumor tissues and ANCTs

SKOV3

miR-145

Hsa_circ_0009910 induces proliferative and motile phenotypes via sponging miR-145 in ovarian cancer cells

[33]

circASH2L

50 pairs of tumor tissues and ANCTs/4-week-old female athymic BALB/c nude mice

A2780, TOV112D, OVCAR-3, SKOV3 and ISOE80

miR-665/VEGFA axis

∆ circASH2L: ↓ invasion and cell growth in vitro, angiogenesis and lymphangiogenesis in vivo

[34]

circ-PGAM1

15 EOC tissues and 15 normal ovary tissues/nude mice

CAOV3, SKOV3, OVCAR3, ES‐2 and 293T cells

miR-542-3p/CDC5L/PEAK1 pathway

∆ circ-PAGM1: ↓ proliferation, migration, and invasion of ovarian cancer cells and ↑ apoptosis

[35]

circRhoC

127 ovarian cancer tissues and 24 normal ovarian tissues

A2780 cells

miR-302e/ VEGFA axis

↑↑ circRhoC: ↑cell viability, migration and invasion via sponging miR-302e

[36]

circPUM1

62 EOC and 13 normal ovarian tissues/5-week-old female BALB/c nude mice

A2780, CAOV3 and HMrSV5

miR-615-5p, miR-6753-5p, NF-κB and MMP2

↑↑ circPUM1: ↑ proliferation, migration, and invasion and ↓ apoptosis

CircPUM1 showed to act on the peritoneum and increase metastasis of cancer in the form of cancer-derived exosomes

[37]

circ_0007841

43 pairs of tumor tissues and ANCTs/6-week-old BALB/c nude mice

SKOV3, OVCAR3 and IOSE80

miR-151-3p/MEX3C axis

∆ circ_0007841: ↓ proliferation, migration and invasion

[38]

hsa_circ_0026123

20 pairs of tumor tissues and ANCTs/4 weeks old female BALB/c nude mice

A2780, TOV112D, SKOV3, OVCAR-3 and ISOE80

miR-124-3p/EZH2 axis

∆ hsa_circ_0026123: ↓ proliferation and metastasis

[39]

circFoxp1

112 EOC patients and 82 healthy controls/nude mice

COC1, OVCAR3, SKOV3, SKOV3/DDP and IOSE-80

miR-22, miR-150-3p, CEBPG and FMNL3

↑↑ circFoxp1: ↑ proliferation and DDP resistance

High levels of circFoxp1 were correlated with lymphatic metastasis, distant metastasis, FIGO stage, primary tumor size, residual tumor diameter, and clinical response

[40]

CircCRIM1

130 ovarian cancer tissues and 24 normal ovarian tissues/4-week-old female BALB/c nude mice

OVCAR3 and CAOV3

miR-145-5p, miR-383-5p, CRIM1 and ZEB2

↑↑ CircCRIM1: ↑ cancer progression in vitro and tumor growth in vivo

[41]

hsa_circ_0061140

4-week-old male BALB/c nude mice

SKOV3 and A2780

miR-370/FOXM1 axis

∆ hsa_circ_0061140: ↓ proliferation and migration

[42]

circ_0061140

20 PTX-resistant human ovarian cancer tissues and 19 PTX-sensitive human ovarian cancer tissues/5-week-old female BALB/c nude mice

SKOV3, HeyA8 and IOSE-80

miR-136/CBX2 axis

∆ circ_0061140: ↓ proliferation, migration and invasion, and ↑ apoptosis and PTX sensitivity

[43]

circ-PVT1

GTEx database

SKOV3 and A2780

miR-149-5p/FOXM1 axis

∆ circ-PVT1: ↓ proliferation, migration and invasion

High levels of PVT1 were correlated with shorter OS in OV patients

[44]

circ-PVT1

–

CAOV3, SKOV3, SNU119, OVCAR3 and HOSEpiC

miR-149

∆ circ-PVT1: ↓ proliferation and ↑ apoptosis

↑↑ circ-PVT1: ↑ proliferation and ↓ apoptosis

[45]

circ_0015756

55 pairs of tumor tissues and ANCTs/5-week-old female BALB/c nude mice

OV90, SKOV3 and IOSE80

miR-942-5p/CUL4B axis

∆ circ_0015756: ↓ proliferation, migration and invasion and ↑ apoptosis

[46]

circ_0025033

39 pairs of tumor tissues and ANCTs/6–8 weeks old female BALB/c mice

KOV3 and A2780 and IOSE80

miR-184/LSM4 axis

∆ circ_0025033: ↓ colony formation, migration, invasion and glycolysis metabolism

[47]

circ_0005276

49 pairs of tumor tissues and ANCTs

CAOV3 and SKOV3

ADAM9

∆ circ_0005276: ↓ migration

High levels of circ_0005276 were associated with lymphatic metastasis and distant metastasis in EOC patients

[48]

circ-NOLC1

118 ovarian cancer tissues, 11 borderline tumor tissues, 11 benign ovarian tissues, 15 normal ovarian tissues/5-week-old female BALB/c nude mice

A2780, CAOV3, ES-2, HO8910, OVCAR3, and SKOV3

ESRP1, CDK1 and RhoA

↑↑ circ-NOLC1: ↑ proliferation, migration, and invasion tumor growth by binding ESRP1 and modulating CDK1 and RhoA expression

[49]

circBIRC6

–

SKOV3, SKOV3/DDP

miR-367-3p

∆ circBIRC6: ↓ proliferation of ovarian cancer cisplatin-resistant cells and ↑ apoptosis

[50]

circ-0001068

20 pairs of tumor tissues and ANCTs 95 OC patients and 53 healthy controls

–

miR-28-5p

Circ-0001068 was found to be delivered into T cells and induced PD1 expression by sponging miR-28-5p

[51]

circRNA051239

30 EOC patients and 10 healthy controls

SKOV3.ip, SKOV3, A2780, CAOV3 and OVCAR3

miR-509-5p/PRSS3 axis

∆ circRNA051239: ↓ proliferation and migration

[52]

circVPS13C

40 pairs of tumor tissues and ANCTs

A2780, SKOV3 and IOSE-80

miR-145 and MEK/ERK signaling

Propofol treatment: ↓ circVPS13C levels and ↑ miR-145 levels, thus ↓ viability, cell cycle and motility and ↑ apoptosis

[53]

circANKRD12

–

PA-1, SKOV3, Caov3, NIH:OVCAR-3 and APOCC

–

Downregulation of circANKRD12 compelled a strong phenotypic change in cell cycle, invasion and migration and metabolism in cancer cells

[54]

VPS13C-has-circ-001567

20 pairs of tumor tissues and ANCTs

SKOV3 and OV-1063

–

∆ VPS13C-has-circ-001567: ↓ proliferation, tumorigenicity and ↑ apoptosis

High levels of VPS13C-has-circ-001567 were associated with tumor node metastasis stage and lymph node metastasis

[55]

circPIP5K1A

25 pairs of tumor tissues and ANCTs/4-week-old BALB/c nude mice

VCAR5, SKOV3, A2780, OV2008 and HCerEpiC

miR-661/IGFBP5 axis

∆ circPIP5K1A: ↓ proliferation, migration and invasion

[56]

circATL2

–

PTX-resistant OC tissues and cells

miR-506-3p/NFIB axis

∆ circATL2: ↓ colony formation, resistance of OC to PTX and ↑ cell cycle arrest and apoptosis in PTX-resistant OC cells

[57]

hsa_circ_0004712

30 pairs of tumor tissues and ANCTs/4–6 weeks old female BALB/c mice

OVCAR-3, SKOV-3 and IOSE-80

miR-331-3p/FZD4 axis

∆ hsa_circ_0004712: ↓ proliferation, colony formation, invasion and migration, and ↑ apoptosis

[58]

CiRS-7

40 pairs of tumor tissues and ANCTs/4-week-old male BALB/c nude mice

SKOV3, A2780, OV2008, IGROV1, ES-2 and HOSE

miR-641/ZEB1 or miR-641/MDM2 axis

∆ CiRS-7: ↓ cell growth and metastasis

High levels of CiRS-7 were correlated with the TNM stages, lymph node metastasis status and overall survival rate in OC patients

[59]

circ-PTK2

26 ovarian cancer tissues and 11 normal ovary tissues/4–5-week-old female nude mice

SK-OV-3 and OVCAR-3

miR-639/FOXC1 axis

↑↑ circ-PTK2: ↑tumor formation, migration and invasion and EMT process

[60]

circLNPEP

40 pairs of tumor tissues and ANCTs/4-week-old male BALB/c nude mice

A2780, SKOV-3, OVCAR3, SK-BR-3, OV-56 and TOV-21 G

miR-876-3p/WNT5A axis

∆ circLNPEP: ↓ cell viability, proliferation, migration, invasion, angiogenesis, and EMT process and ↑ apoptosis

[61]

circNRIP1

56 pairs of tumor tissues and ANCTs/BALB/c nude mice

HOEC, A2780, SKOV3 and A2780/PTX and SKOV3/PTX

miR-211-5p/HOXC8 axis

∆ circNRIP1: ↓ PTX resistance of OC cells in vitro and OC tumor in vivo

[62]

circTNPO3

48 pairs of tumor tissues and ANCTs/nude mice

SKOV3, HeyA-8 and IOSE-80

miR-1299/NEK2 axis

∆ circTNPO3: ↑ sensitivity to PTX via promoting PTX-induced apoptosis in vitro and in vivo

[63]

hsa_circ_0051240

10 pairs of tumor tissues and ANCTs/6-week-old male nude mice

CAOV-3, SKOV-3, OVCAR-3 and H8910 and HOSE

miR-637/KLK4 axis

∆ hsa_circ_0051240: ↓ cell proliferation, migration and invasion in vitro, and tumor formation in vivo

[64]

circSETDB1

73 pairs of tumor tissues and ANCTs/4–6-week-old female BALB/c nude mice

A2780, SKOV3, IOSE-80 and 293 T cells

miR-129-3p/MAP3K3 pathway

∆ circSETDB1: ↓ cell proliferation, migration, invasion and ↑ apoptosis

[65]

circSETDB1

60 SOC patients [18 primary chemoresistance, 42 primary chemosensitive] and 60 healthy controls

–

–

High levels of circSETDB1

Were correlated with advanced clinical stage, lymph node metastasis and a shorter PFS time of SOC patients

[66]

hsa_circ_0000714

–

SKOV3, A2780, SKOV3/PTX and A2780/PTX

miR-370-3p/RAB17 axis and CDK6/RB signaling pathway

Hsa_circ_0000714 was found to regulate RAB17 expression via sponging miR-370-3p, and through the CDK6/RB signaling pathway, so it showed to play a role in the malignant progression of the paclitaxel-resistant ovarian cancer cell A2780/PTX

[67]

circ_MUC16

30 pairs of tumor tissues and ANCTs/female BALB/c nude mice

A2780, SK-OV-3 and IOSE-80

miR-1182/S100B axis

∆ circ_MUC16: ↓ proliferation, glycolysis metabolism, migration and invasion

↑↑ circ_MUC16: ↓ effects of Propofol to promote the aggressive behaviors of ovarian cancer via sponging miR-1182

[68]

circ-FAM53B

54 pairs of tumor tissues and ANCTs

HO8910, SKOV3, OVCAR3, A2780 and IOSE80

miR-647, VAMP2 and MDM2

↑↑ circ-FAM53B: ↑ proliferation, migration, and invasion

High levels of circ-FAM53B were correlated with clinical severity and poor prognosis of OC patients

[69]

circ-ABCB10

103 EOC tumor tissues and 53 EOC adjacent tissues as control

OVCAR3, UWB1.289, SKOV3, CAOV3 and IOSE80

miR-1271, miR-1252 and miR-203

High levels of circ-ABCB10 were associated with poor differentiation, large tumor size and advanced FIGO stage and worse OS in EOC patients

↑↑ circ-ABCB10: ↑ proliferation and ↓ apoptosis

[70]

circ-ABCB10

–

OVCAR3, UWB1.289, SKOV3, CAOV3 and IOSE80

miR-1271, Capn4/Wnt/β-catenin signaling

↑↑ circ-ABCB10: ↑ proliferation, invasion, Capn4/Wnt/β-catenin signaling pathway, ↓ apoptosis via sponging miR-1271

[71]

circ-CSPP1

12 borderline tumors, 117 ovarian carcinomas tissues, 12 benign ovarian tissues and 15 normal ovarian tissues

AOV3, A2780, OVCAR3

miR-1236-3p/ZEB1 axis

∆ circ-CSPP1: ↓ cell growth, migration, invasion, and EMT process

High levels of circ-CSPP1 were associated with correlated with FIGO staging and differentiation

[72]

circ_0002711

54 pairs of tumor tissues and ANCTs/nude mice

SKOV3, OV90 and IOSE80

miR-1244/ROCK1 axis

∆ circ_0002711: ↓ cell viability, colony formation ability and aerobic glycolysis

[73]

circE2F2

–

OC tissues and cell lines

–

↑↑ circE2F2: ↑ proliferation, cell growth, metastasis, and glucose metabolism by stabilizing the E2F2 mRNA

High levels of circE2F2 could strengthen the stability of the E2F2 mRNA through binding to the HuR protein

High levels of circE2F2 were correlated with poor OS in OC patients

[74]

circHIPK2

46 pairs of tumor tissues and ANCTs/4–5-week-old female BALB/c-nude mice

SKOV3, A2780, SKOV3/DDP and A2780/DDP and IOSE80

miR-338-3p/CHTOP axis

∆ circHIPK2: ↓ cell proliferation, cell cycle entrance, migration and invasion in SKOV3/DDP and A2780/DDP cells and ↑ apoptosis and suppresses the 50% inhibitory concentration of DDP

[75]

circ_0000745

50 pairs of tumor tissues and ANCTs/4-week-old BALB/c nude mice

CoC1, ES-2, SW626, SK-OV-3 and IOSE-80

miR-3187-3p/ERBB4 axis and PI3K/AKT signaling pathway

∆ circ_0000745: ↓ proliferation, aggressiveness, EMT process, and stemness of SK-OV-3 cells

[76]