Fig. 3

Activation of the CXCR3 pathway affects the immune microenvironment of mUC. A The Heatmap shows the expression levels of immune-related genes between CXCR3-high and CXCR3-low patients. The color in the first column of the heatmap represents the immune functions of the genes. The second and third columns represent the p-value and logFC analysis of the differential gene expression analysis in the ICI cohort, while the fourth and fifth are representatives of the TCGA-BLCA cohort. The color represents the size of logFC shown in the middle of the rectangles. LogFC > 0 means that the genes are highly expressed in CXCR3-high patients, while logFC < 0 is the opposite. B The box plot shows the differences in 22 immune cells between CXCR3-high and CXCR3-low groups according to the CIBERSORT analysis results from the ICI cohort. C The box plot shows the difference in 22 immune cells between CXCR3-high and CXCR3-low groups according to the CIBERSORT analysis results from theTCGA-BLCA cohort. D The correlation between CXCR3 pathway activation and the proportion of CD8+ T cells in the ICI cohort. E The correlation between CXCR3 pathway activation and the proportion of Tregs in the ICI cohort. F The correlation between CXCR3 pathway activation and the proportion of CD8+ T cells in the TCGA-BLCA cohort. G The correlation between CXCR3 pathway activation and the proportion of Tregs in the TCGA-BLCA cohort