Fig. 4

Analyses of immune cell infiltration. A Correlations of IRGPI with immune cell infiltration (The blue and red violin represented the IRGPI LR and HR group, respectively. The white points inside the violin implicated median values). B, C Significant correlations of 3-IRGs (CD70, CXCL11, HGF) with M0 macrophages, M1 macrophages and M2 macrophages in MM. D A brief process for M2 macrophage induction. The CD206 expression of M2 macrophages was determined by flow Cytometry (E) and Western blot analysis (F). G qRT-PCR analysis of 3-IRGs after MM cells co-cultured with M2 macrophages. Data were presented as the mean ± SD from three independent experiments. *p < 0.05; **p < 0.01, ***p < 0.001