Fig. 5

INPP5B-involved protein–protein interaction network. a–c The INPP5B-involved protein–protein interaction network constructed by STRING database (a) and GeneMANIA database (b), respectively. The intersections of above datasets identified as key genes (c). d The expression relationship between INPP5B and PTEN in lung adenocarcinoma from TCGA database. e Expression of PTEN in LUAD tissues (TCGA) and healthy lung tissues (TCGA and GTEx) by RNASeq. f Survival analysis of PTEN in LUAD determined by Kaplan–Meier plotter database. g Co-immunoprecipitation of exogenous INPP5B with exogenous PTEN in HEK293 cells. h Co-immunoprecipitation of endogenous PTEN with endogenous INPP5B in A549 cells