Table 1 Expression of DANCR in cell lines

Acute myeloid leukemia

miR-874-3P/ATG16L1 axis

HL60, U937, and KG1a

DANCR is involved in Ara‐C resistance and promotes autophagy in HL60 cells via regulating ATG16L1

[33]

Bladder cancer

miR-335/VEGF-C axis

SW780, 5637, T24, UM-UC-3, SV-HUC-1, and T24

∆ DANCR: ↓proliferation, migration, invasion and lymphatic metastases

[7]

IL-11-STAT3 signaling and CCND1

UM-UC-3, T24 and 293T

DANCR was found to promote bladder cancer progression

[8]

miR-149/MSI2 axis

5637, SW780, UM-UC-3, T24 and SV-HUC-1

∆ DANCR: ↓ proliferation, migration, invasion and EMT process

[9]

Breast cancer

PI3K/AKT signaling

BT549, MCF7, T47D, MDA-MB-231, MDA-MB-453, and MDA-MB-468 and MCF10A

∆ DANCR: ↓ proliferation and tumor growth

DANCR is involved in enhancing PI3K/AKT signaling by binding with RXRA and increasing its serine 49/78 phosphorylation

[27]

miR-4319/VAPB axis

MCF-10A, MCF-7 and HCC38

∆ DANCR: ↓ proliferation, migration, invasion, and ↑ apoptosis

[28]

EZH2, SOCS3

MCF10A, MCF7, T47D, MDA‐MB‐231, and MDA‐MB‐468

∆ DANCR: ↓ viability, migration and invasion

DANCR epigenetically inhibits SOCS3 expression

[29]

miR-758-3p-PAX6 axis

HCC1937, 1590, ZR-75-30, MDA-MB-468 and MCF-10A

∆ DANCR: ↓ proliferation and ↑ apoptosis

[34]

miR-216a-5p

MCF-7, MDA-MB-231 and MCF-10A

∆ DANCR: ↓ proliferation, migration, and invasion

[35]

miR-874-3p/SOX2 axis

MCF10A, ZR751, MCF7, SKBR3, BT474, MDA-MB-231, MDA-MB-468 cells

∆ DANCR: ↓ proliferation

TUFT1 induces the expression of DANCR

[36]

EZH2, CD44 and ABCG2

Hs578Bst, MCF-7, T47D, MDA-MB-468 and MDA-MB-231

∆ DANCR: ↓ proliferation and invasion and ↑ binding of EZH2 on the promoters of CD44 and ABCG2, so reduction of expression of these genes

[37]

PRC2, Wnt/EMT signaling

HMECs, MCF7, ZR-75–1, MDA-MB-231, Hs578T, and BT549

RGD-PEG-ECO/siDANCR nanoparticles: ↓ proliferation, invasion and migration

[38]

Cervical cancer

miR-335-5p/ROCK1 axis

aski, SW756, SiHa, C33A, HeLa, ME‐180, and End1/E6E7

∆ DANCR: ↓ proliferation, migration, and invasion

[39]

FRAT1, FRAT2 and Wnt/β-catenin signaling pathway

HCerEpiC, HeLa, SiHa, C-33A, and ME-180

∆ DANCR: ↓ proliferation

FRAT1 and FRAT2 are up-regulated by DANCR and the Wnt/β-catenin signaling pathway is activated by DANCR

[40]

miR-145-3p/ZEB1 axis and KLF5

HeLa, SiHa, and H8

KLF5-induced up-regulation of DANCR up-regulates ZEB1 via sponging miR-145-3p to promote the progression of cervical cancer

[41]

miR-665/TGFBR1 axis and ERK/SMAD pathway

Endl/E6E7 and H8

↑↑ miR-665 (a target of DANCR): ↓ proliferation, migration, and invasion

miR-665 reduces TGFBR1 levels and inactivates ERK/SMAD pathway

[42]

miR-345-5p/Twist1 axis

HuH28, HuCCT1, SG231, and H69

∆ DANCR: ↓ proliferation, migration, invasion, EMT and angiogenesis and ↑ apoptosis

[43]

Cholangiocarcinoma

EZH2 and FBP1

HuCCT1 and RBE

∆ DANCR: ↓ proliferation, migration

DANCR could modulate the histone methylation of promoter of FBP1by binding with EZH2

[44]

miR-125b-5p/HK2 axis

HT-29, SW620, HCT116, SW480, DLD-1, and CRL-1790

∆ DANCR: ↓ glycolysis rate and ↑ cisplatin sensitivity

[21]

Colorectal cancer

miR-518a-3p/MDM2 axis, Smad2/3 and p53

HT29, HCT116, SW116, Caco-2, and FHC

∆ DANCR: ↓ proliferation, viability, metastasis

[22]

–

SW620, SW480, HCT116, HT29, HCT15, Caco-2, and HCoEpiC

∆ DANCR: ↓ proliferation, colony formation, and ↑ apoptosis

[45]

MALAT1 and QK

HCT116, RKO, SW620, HT-29, and LoVo

DANCR inhibits Doxorubicin-induced apoptosis via enhancing the RNA stability of MALAT1 and interacting with QK

[23]

miR-185-5p/HMGA2 axis

NCM460 and the CRC cell lines LoVo, SW620, SW480, and HT29

∆ DANCR: ↓ proliferation, migration, invasion and cell cycle progression, and ↑ apoptosis

[46]

KAT6A

LOVO, SW480, HCT116, SW620, and HT29

∆ DANCR: ↓ proliferation, cell cycle progression, and tumorigenesis

DANCR was found to bind with lysine acetyltransferase 6A to mediate KAT6A acetyltransferase activity

[47]

miR-145-5p/NRAS axis

–

DANCR showed an indirect effect on NRAS expression levels via targeting miR-145-5p

[48]

miR-577/HSP27 axis

HT29, HCT116, SW480, and LOVO and NCM460

∆ DANCR: ↓ proliferation and metastasis

[49]

miR-214

KLE, RL95-2, ishikawa, AN3CA, and HEC-1B

∆ DANCR: ↓ proliferation and ↑ apoptosis

[50]

Endometrial carcinoma

ZNF750, and miR-4707-3p/FOXC2 axis

SHEE, KYSE140, KYSE150, KYSE180, KYSE410, KYSE510, KYSE450, Colo680N, and ECA109

Down-regulation of ZNF750 induces DANCR expression, thus inhibits miR-4707-3p to interact with FOXC2, resulting in enhanced FOXC2 signaling and angiogenesis

[51]

Esophageal squamous cell carcinoma

miR-33a-5p/ZEB1 axis

EC9706, EC109, EC1, KYSE150, and Het-1A

↑↑ miR-33a-5p (a target of DANCR): ↓ proliferation and metastasis

[52]

–

ECA109 and TE-1

∆ DANCR: ↓ proliferation, migration, invasion, and ↑ apoptosis

[53]

Gastric cancer

MDR1 and MRP1

SGC7901 and BGC823

∆ DANCR: ↓ survival and increased apoptosis

[30]

miR-194/AKT2 axis and

SGC7901, MGC-803, NCI-N87, and GES-1

∆ DANCR: ↓ viability, ↑ autophagy, and apoptosis

KLF5 is involved in activating the transcription of DANCR

[31]

SALL4 and β-catenin pathway

GES-1, BGC-823, MGC-803, HGC-27 and MKN-45

∆ DANCR: ↓ proliferation, migration, invasion and EMT process, ↑ cell cycle arrest and apoptosis

DANCR activated by SALL4 plays its oncogenic roles via the activation of β-catenin pathway

[32]

–

SGC7901, MGC803, and MKN-45

∆ DANCR: ↓ proliferation, and ↑ cell cycle arrest

[54]

Glioma

miR-135a-5p/BMI1 axis

LN229, U251 and NHAs

∆ DANCR: ↓ proliferation, migration and invasion

[55]

miR-33a-5p

HEB, U87, U251, LN22 9 and T98G

∆ DANCR: ↓ proliferation, migration, and EMT process, and ↑ apoptosis

[56]

Wnt/β-catenin signaling

U87, U251, SGC7901 and BGC823

∆ DANCR: ↓ proliferation, migration, and EMT process

[57]

miR-33a-5p, miR-33b-5p, miR-1-3p, miR-206, and miR-613/AXL axis and PI3K/Akt/NF-κB signaling pathway

U87MG, U251MG, LN18 and U138MG

↑↑ DANCR: ↓ sensitivity of glioma cells to cisplatin

∆ DANCR: ↑ sensitivity of glioma cells to cisplatin

DANCR up-regulates AXL to actives PI3K/Akt/NF-κB signaling pathway

[58]

miR-634/RAB1A axis

U251, U118, LN229, U87MG, and NHA

∆ DANCR: ↓ proliferation and ↑ G0/G1 phase arrest

[59]

miR-216a/LGR5, PI3K/AKT

SHG-44, U87MG, U118MG, and U251MG

∆ DANCR: ↓ proliferation, migration, invasion, angiogenesis, and ↑ phase arrest and apoptosis

[60]

IGF2BP2, FOXO1, PID1

U251MG, LN229, LN18, T98G, and HEK293T

IGF2BP2 increases DANCR stability and decreases DANCR methylation. DANCR indices ubiquitination of FOXO1 via interacting with FOXO1. PID1 promoted by FOXO1 enhances the chemotherapy sensitivity of GBM cells

[61]

miR-125b-5p/MAPK pathway axis

HepG2 and Huh-7 cells

∆ DANCR: ↓ migration, invasion

[15]

Hepatocellular carcinoma

miR-216a-5p/KLF12 axis

Huh7, HepG2 and LO2 cells

∆ DANCR: ↓ proliferation, migration, invasion and ↑ apoptosis

[16]

miR-222-3p/ ATG7 axis

Bel7407, Hep3B, HepG2, Huh7, MHCC97H and LO2

∆ DANCR: ↓ proliferation and autophagy

[17]

PSMD10-IL-6/STAT3 signaling axis

HEK-293T, Huh7 and Hep3B

DANCR promotes sorafenib resistance via PSMD10-IL-6/STAT3 signaling axis

[18]

CTNNB1

HCC cells

DANCR is involved in stemness features of hepatocellular carcinoma by derepression of CTNNB1

[19]

miR-27a-3p/ROCK1/LIMK1/COFILIN1 pathway axis

MHCC‐97H, Huh7, HCC‐LM3, HepG2, MHCC‐97L, Hep3B, SMMC‐7721 and LO2

∆ DANCR: ↓ proliferation, and metastasis

[20]

β-catenin pathway

SMMC-7721 and HCCLM3

∆ DANCR: ↓ proliferation and metastasis

[62]

miR-216a

BEAS-2B, NCI-H1299, A549, and NCI-H1975

∆ DANCR: ↓ proliferation and colony formation

[10]

Lung cancer

miR-1225-3p/ ErbB2 axis

16HBE, A549, SPCA1, H1299 and H1975

∆ DANCR: ↓ Migration and Invasion

[11]

miR-214-5p/CIZ1 axis

16HBE, A549, SPCA1, H1299, and H358

∆ DANCR: ↓ proliferation and ↑ apoptosis

[13]

miR-496/mTOR axis

A549, H1299, H358, (HEK) 293T cells and HBE

∆ DANCR: ↓ proliferation, migration, invasion and ↑ apoptosis

[12]

HMGA2

16HBE, SPCA1, A549, H1299 and H1975

∆ DANCR: ↓ invasion

↑↑ DANCR: ↑ invasion via increasing HMGA2

[63]

miR-216a and Wnt/β-catenin pathway

A549, H1975, H1755, H1944, H2087, H358, H661 and H1299

∆ DANCR: ↓ proliferation, stemness, migration, invasion

[14]

p21

A549, H1299, H358 and BEAS-2B

∆ DANCR: ↓ proliferation, migration, invasion EMT process, ↑ apoptosis and cell cycle arrest

DANCR inhibits p21 expression

[64]

miR-138/Sox4 axis

NHBE, HEK-293T, A549, H1299, H460, SK-MES-1, and Calu-3

∆ DANCR: ↓ proliferation, migration, invasion EMT process, and ↑ apoptosis

[65]

miR-758-3p

SPC-A, NCL-H1650, NCL-H1975, SK-MES-1, A549, NCL-H358, NCI-H1299 and 16HBE

∆ DANCR: ↓ viability, proliferation and ↑ cell cycle arrest

[66]

–

HT-29 and FHC

∆ DANCR: ↓ proliferation, migration, invasion EMT process, and metastasis

[67]

miR-135b-5p/KLF9 axis

MM cells

∆ DANCR: ↓ proliferation, migration, and invasion

[68]

Multiple myeloma

IL-6/JAK1/STAT3 signaling

NP460, CNE1, CNE2, HNE1, HNE2, HONE1, 5–8 F, and 6-10B

∆ DANCR: ↓ proliferation and invasion

IL-6 is involved in DANCR expression upregulation via an STAT3-dependent manner

DANCR interacts with STAT3 and enhances JAK1 binding to STAT3

[69]

Nasopharyngeal carcinoma

RBM3 and SOX2

C666-1, SUNE-1, HNE-1, CNE1, CNE2, and NP69

∆ DANCR: ↓ proliferation, colony formation

DANCR functions as an oncogene via binding to RBM3 to stabilize SOX2 mRNA

[70]

PTEN, AKT

5-8F, SUNE-1, C666-1, and NP69

∆ DANCR: ↓ proliferation, colony formation, and migration, and ↑ apoptosis

DANCR is involved in expression of PTEN

[71]

EZH2 and PTEN

SUNE-1 and 5-8F

∆ DANCR: ↓ cell growth and migration

DANCR mediates the binding of EZH2 on PTEN promoter to down-regulate PTEN expression

[72]

HIF-1α, NF90/NF45 complex

SUNE-1, HONE-1, CNE-1, CNE-2, HNE-1, 5-8F, 6-10B and C666-1, and S18 and S26

∆ DANCR: ↓ migration and invasion

DANCR increases stability of HIF-1α mRNAs

[73]

miR-338-3p/B4GALT3 axis

neuroblastoma cells

∆ DANCR: ↓ proliferation and ↑ apoptosis

[74]

Neuroblastoma

miR-216a-5p/Bcl-2/KLF12 axis

SCC9, SCC15, SCC25, CAL-27 and Tca8113, and NHOKs

∆ DANCR: ↓ proliferation, migration, invasion, and ↑ apoptosis

[75]

Oral squamous cell carcinoma

miR-335-5p/miR-1972/ROCK1 axis

MG-63, U2OS, MNNG/HOS, 143B and hFOB 1.19

∆ DANCR: ↓ proliferation, migration, invasion and metastasis

[3]

Osteosarcoma

miR-33a-5p/AXL axis, PI3K-Akt signaling pathway

MG63, U2OS, SaOS2, HOS, and 143B

FOB, and fibroblast NIH3T3 and 293T

∆ DANCR: ↓ proliferation, migration, invasion

[2]

miR-149/MSI2 axis

hFOB1.19 and Saos-2

∆ DANCR: ↓ proliferation, migration, invasion

[4]

miR-216a-5p/SOX5 axis

MG-63, U2OS, 143B and hFOB 1.19

∆ DANCR: ↓ proliferation, migration, invasion and autophagy and ↑ apoptosis

[5]

METTL3

Saos-2, SJSA-1, MG63, HOS, and U-2 OS, and hFOB 1.19

∆ DANCR: ↓ proliferation, migration, invasion

METTL3 was found to regulate DANCR expression by m6A modification-mediated DANCR mRNA stability

[6]

SP1

CAOV3, SKOV3, A2780

∆ DANCR: ↓ viability, migration and invasion

SP1 could induce DANCR expression by binding to the promoter region of DANCR in ovarian cancer tissues and cells

[76]

Ovarian cancer

miR-214/TGF-ß axis

A2780 and SKOV3

∆ DANCR: ↓ viability, migration and invasion, and ↑ apoptosis

[77]

miR-145/VEGF axis

A2780, PA‐1, SKOV3, HO8910, and HOEC

∆ DANCR: ↓ tube formation, angiogenesis, and invasion

[78]

UPF1

IOSE-386, SKOV-3, OVCAR3, HO8910, and HEY

↑↑ DANCR: ↑ proliferation, migration via negatively regulating UPF1 level

[79]

miR-33b/MMP16 axis

AsPC‐1, PANC‐1, CFPAC‐1, SW1990, BxPC‐3 and HPDE6‐C7

∆ DANCR: ↓ proliferation, migration, and invasion and EMT process

[24]

Pancreatic cancer

miR-214-5p/E2F2 axis

PANC-1, SW1990, CAPAN-1, BxPC-3, AsPC-1 and HPDE6-C7

∆ DANCR: ↓ growth and metastasis

[25]

miR-33a-5p/AXL axis

Panc1, Panc28, AsPC1, MiaPaCa2 and BxPC3 and HPDE

∆ DANCR: ↓ proliferation, and colony formation

[80]

miR-135a /NLRP3 axis

BxPC-3, MIA-PaCa-2, CFPAC-1, PANC-1, SW1990 and HPDE6-C7

∆ DANCR: ↓ proliferation and invasion

[26]

miR-135a

RWPE-1, PC3, C4-2 and DU145

∆ DANCR: ↑ Paclitaxel Sensitivity

[81]

Prostate cancer

miR-185-5p/LASP1 axis and FAK/PI3K/AKT/GSK3β/Snail pathway

C4-2, PC3, DU145, LNCaP, 22RV1, and RWPE-1

∆ DANCR: ↓ proliferation, migration, invasion, G1-S transition and EMT process

[82]

miR-214-5p/TGF-β axis

DU145, 22Rv1, RC-92a, PC-3M and RWPE-1

↑↑ DANCR: ↑ proliferation and migration, and ↓ apoptosis

[83]

miR-34a-5p/JAG1 axis

DU145 and PC3

∆ DANCR: ↑ sensitivity to docetaxel

[84]

TIMP2/3, EZH2

CWR22Rv1, PC-3, and C4-2B

∆ DANCR: ↓ migration and invasion

↑↑ DANCR: ↑ invasion and metastasis

[85]

–

786-O and ACHN

↑↑ DANCR: ↓ proliferation, migration and invasion, and ↑ apoptosis

[86]

Renal cell carcinoma

miR-34c and miR-613/ MMP-9 axis

Weri-Rb1, Y79, SO-RB50, HXO-RB44, ARPE-19, and hTERT-RPE1

∆ DANCR: ↓ proliferation, migration, invasion, and EMT process

[87]

Retinoblastoma

miR-135a-5p/KLF8 axis and MMP-2/9

SCC9, TSCCA, TCa-8113, CAL-27 cells, and SCC9

∆ DANCR: ↓ proliferation, viability, migration and invasion

[88]

Tongue squamous cell carcinoma