Fig. 1

The landscape of genetic alterations of m6A regulators in PAAD. A GO enrichment analysis of 23 m6A regulators. The x-axis indicates the gene ratio for each GO term. B Eight of the 178 PAAD patients experienced genetic alterations in 23 m6A regulators, with a frequency of 4.49%, mostly including missense mutations, multi-hit, and deep deletions. The numbers on the right indicate the mutation frequency of each regulator. Each column represents the individual patient. C The CNV mutation frequency of 23 m6A regulators was prevalent. The column represents the frequency of the alterations. Deletion frequency, green dot; amplification frequency, red dot. D Location of CNV alterations in m6A regulators on chromosomes. E Broad co-expression correlations among the 23 m6A RNA modification regulators in PAAD. “X” means P ≥ 0.05. F Difference in mRNA expression levels of 23 m6A regulators between normal and PAAD samples. Asterisks (*) represent the statistical P-values (*P < 0.05, **P < 0.01, and ***P < 0.001).