Fig. 3

Downregulation of circ-EPB41 suppressed NSCLC invasion both in vitro and in vivo. A, B Cell invasion was assessed in both A549 and H1650 cells using Transwell assays. Data are presented as means ± SD; ***P < 0.001 vs NC. C Live imaging showing the effects of circ-EPB41 on the metastasis of A549 cells 30 days after intravenous tail injection in different groups. D–F The numbers of metastatic foci in lung tissues were caculation according to the HE staining. The data are expressed as the mean ± SD. ***p < 0.001 vs NC