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Fig. 2 | Cancer Cell International

Fig. 2

From: Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Fig. 2

Summarized scheme with anticancer mechanisms of Vinca alkaloids and colchicine. These compounds stop the mitotic cell cycle by attaching to the surface of two tubulin heterodimers next to the exchangeable GTP-binding site, causing microtubule depolymerization. Destabilization and interruption in tubulin dynamics result in programmed cell death or apoptosis

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Cancer Cell International

ISSN: 1475-2867

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