Fig. 5

CTLs induced by CD40 Ab and OK-432 augmented the killing efficiency of tumors on lungs in colon cancer models with pulmonary metastasis. A Lungs derived from mouse models treated with different types of CTLs. The mice involved in this experiment were divided into seven groups. All CTLs administered to colon cancer models with pulmonary metastasis were induced by corresponding DCs. They could suppress the expansion of lungs in the mouse model. DCs activated by CD40 Ab and OK-432 elicited the most efficient CTLs, which further restrained the expansion of lungs compared with individual agents. B Statistics of the lung to body weight ratio (mg/g) corresponding to A. C H&E staining of lung slides. H&E staining was used to observe the lung morphology. Each group was presented with a magnified image. The combinational group showed the least number of tumor cells compared with the others. D Statistics of tumor nodes corresponding to C. Value represents mean ± standard error of mean. P-value represents the comparison of control group versus tested groups