Fig. 2
From: Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders
MIR4435-2HG exerts its oncogenic role via different mechanisms in the progression of GC. MIR4435-2HG acts as a molecular sponge for miR-497 and miR-138-5p; therefore, it enhances the expression of NTRK3 and SOX4 (respectively), which results in cell proliferation, migration, and invasion. Also, an elevated level of MIR4435-2HG activates the TGF-β/SMAD signaling pathway, promotes EMT and suppresses apoptosis