Fig. 3
From: Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders
The impact of MIR4435-2HG in the progression of HCC through different mechanisms. MIR4435-2HG increases promoter methylation of E-cadherin and p21 via mediating the accumulation of EZH2 in the promoter region. MIR4435-2HG increases HCC progression via blocking E-cadherin and p21 expression. In addition, MIR4435-2HG promotes cell proliferation, migration, invasion, and EMT via activation of MAPK/ERK and PI3K/AKT signaling pathways. The effect of MIR4435-2HG is exerted via sponging miR-136-5p and interaction with miR-487a