Table 1 MIR4435-2HG participates in the pathogenesis of different cancers via the regulation of different miRNAs (∆: knock-down, EMT: Epithelial-Mesenchymal Transition, TNBC: Triple‐negative breast cancer, NSCLC: non‑small cell lung cancer, HNSCC: head and neck squamous cell carcinoma)
From: Long non-coding RNA MIR4435-2HG: a key molecule in progression of cancer and non-cancerous disorders
Cancer type | MIR4435-2HG | miRNA | Target gene | Function | References |
|---|---|---|---|---|---|
Colorectal cancer | Up-regulated | ↓miR-206 | ↑YAP1 | ∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation, ↓EMT, ↓CRC growth, ↓Liver metastasis | [18] |
Gastric cancer | Up-regulated | ↓miR-497 | ↑ NTRK3 | ∆ MIR4435-2HG: ↓Cell proliferation, ↓Metastasis, ↑Apoptosis | [28] |
Gastric cancer | Up-regulated | ↓miR-138-5p | ↑SOX4 | ∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation, ↓EMT, ↑Apoptosis, ↓Tumor growth | [29] |
Hepatocellular carcinoma | Up-regulated | ↑miRNA-487a | – | ↑MIR4435-2HG: ↑miRNA-487a, ↑Cell proliferation, | [35] |
Hepatocellular carcinoma | Up-regulated | ↓miR‑136‑5p | ↑B3GNT5 | ∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation | [38] |
NSCLC | Up-regulated | ↓miR-6754-5p | – | ∆ MIR4435-2HG: ↓Invasion, ↓Migration, ↓Cell proliferation, ↑Apoptosis | [45] |
Breast cancer | Up-regulated | ↓miR-22-3p | ↑TMEM9B | ∆ MIR4435-2HG: ↓viability, ↓Invasion, ↓Migration, ↓Cell proliferation, ↓EMT | [48] |
Ovarian cancer | Up-regulated | ↓miR-128-3p | ↑CDK14 | ∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration, ↓Tumor growth, ↑Apoptosis | [51] |
Glioma cancer | Up-regulated | ↓miR-1224-5p | ↑TGFBR2 | ∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Tumor growth | [58] |
Glioma cancer | Up-regulated | ↓miR- 125a- 5p | ↑TAZ | ∆ MIR4435-2HG: ↓Migration, ↓Cell proliferation, ↑Apoptosis, ↓Wnt pathway, ↓Tumor volume | [61] |
Cervical cancer | Up-regulated | ↓miR-128-3p | ↑MSI2 | ∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration | [66] |
Bladder cancer | Up-regulated | ↓miR-4288 | – | ∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration | [71] |
HNSCC | Up-regulated | ↓miR‑383‑5p | ↑RBM3 | ∆ MIR4435-2HG: ↓Cell proliferation, ↓Invasion, ↓Migration, ↓EMT, ↓Tumor growth | [70] |
Melanoma | Up-regulated | ↓miR-802 | ↑FLOT2 | ↑MIR4435-2HG: ↑Cell proliferation, ↑Invasion, ↑Migration | [72] |
TNBC | Up-regulated | ↑miRNA‐21 | - | ↑MIR4435-2HG: ↑cell viability, ↑cell proliferation, ↑chemoresistance | [49] |
NSCLC | Up-regulated | ↓miRNA-204 | ↑CDK6 | ∆ MIR4435-2HG: ↓cell proliferation, ↓invasion, ↓migration | [46] |