Fig. 4

Correlation of TXNIP expression with immune infiltration level in different tumors of TCGA. A Correlation of TXNIP expression with infiltration level of B cell, CD4⁺ T cell, CD8⁺ T cell, neutrophil, dendritic cell, macrophage, monocyte, and regulatory T lymphocyte. B–D TXNIP expression was significantly positively related to the levels of infiltrating B cell, CD4⁺ T cell, CD8⁺ T cell, neutrophil, macrophage and dendritic cell in BRCA, LUAD and KIRC. E Correlation of TXNIP expression with immune infiltration of cancer-associated fibroblast. F–M TXNIP expression has significant negative correlations with tumor purity but was significantly positively correlated with the levels of infiltrating cancer-associated fibroblast in BRCA, BRCA-Basal, COAD, LIHC, LUSC, READ, STAD, and TGCT. BRCA breast invasive carcinoma, LUAD lung adenocarcinoma, KIRC kidney renal clear cell carcinoma, COAD colon adenocarcinoma, LIHC liver hepatocellular carcinoma, LUSC lung squamous cell carcinoma, READ rectum adenocarcinoma, STAD stomach adenocarcinoma, TGCT testicular germ cell tumors